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Delbrouck, C.* ; Kiweler, N.* ; Chen, O.* ; Pozdeev, V.I.* ; Haase, L.* ; Neises, L.* ; Oudin, A.* ; Fouquier d'Hérouël, A.* ; Shen, R. ; Schlicker, L.* ; Halder, R.* ; Lesur, A.* ; Schuster, A.* ; Lorenz, N.I.* ; Jaeger, C.* ; Feucherolles, M.* ; Frache, G.* ; Szpakowska, M.* ; Chevigne, A.* ; Ronellenfitsch, M.W.* ; Moussay, E.* ; Piraud, M. ; Skupin, A.* ; Schulze, A.* ; Niclou, S.P.* ; Letellier, E.* ; Meiser, J.*

Formate promotes invasion and metastasis in reliance on lipid metabolism.

Cell Rep. 42:113034 (2023)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Metabolic rewiring is essential for cancer onset and progression. We previously showed that one-carbon metabolism-dependent formate production often exceeds the anabolic demand of cancer cells, resulting in formate overflow. Furthermore, we showed that increased extracellular formate concentrations promote the in vitro invasiveness of glioblastoma cells. Here, we substantiate these initial observations with ex vivo and in vivo experiments. We also show that exposure to exogeneous formate can prime cancer cells toward a pro-invasive phenotype leading to increased metastasis formation in vivo. Our results suggest that the increased local formate concentration within the tumor microenvironment can be one factor to promote metastases. Additionally, we describe a mechanistic interplay between formate-dependent increased invasiveness and adaptations of lipid metabolism and matrix metalloproteinase activity. Our findings consolidate the role of formate as pro-invasive metabolite and warrant further research to better understand the interplay between formate and lipid metabolism.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cancer Metastasis ; Cp: Cancer ; Cp: Metabolism ; Formate Overflow ; Invasion ; One-carbon Metabolism; Cancer; Acid; Serine
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Journal Cell Reports
Quellenangaben Volume: 42, Issue: 9, Pages: , Article Number: 113034 Supplement: ,
Publisher Cell Press
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status Peer reviewed
Institute(s) Helmholtz Artifical Intelligence Cooperation Unit (HAICU)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-530001-001
Grants
FNR-BRIDGE program
Televie
FNR-INTER program
DFG-fellowship
FNR-ATTRACT program
DOI 10.1016/j.celrep.2023.113034
WOS ID 001093464200001
Scopus ID 85169832515
PubMed ID 37651228
Erfassungsdatum 2023-10-18
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