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Knoedler, S. ; Broichhausen, S.* ; Guo, R. ; Dai, R. ; Knoedler, L.* ; Kauke-Navarro, M.* ; Diatta, F.* ; Pomahac, B.* ; Machens, H.G.* ; Jiang, D. ; Rinkevich, Y.

Fibroblasts – the cellular choreographers of wound healing.

Front. Immunol. 14:1233800 (2023)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Injuries to our skin trigger a cascade of spatially- and temporally-synchronized healing processes. During such endogenous wound repair, the role of fibroblasts is multifaceted, ranging from the activation and recruitment of innate immune cells through the synthesis and deposition of scar tissue to the conveyor belt-like transport of fascial connective tissue into wounds. A comprehensive understanding of fibroblast diversity and versatility in the healing machinery may help to decipher wound pathologies whilst laying the foundation for novel treatment modalities. In this review, we portray the diversity of fibroblasts and delineate their unique wound healing functions. In addition, we discuss future directions through a clinical-translational lens.
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Publication type Article: Journal article
Document type Review
Keywords Fascia ; Fibroblast ; Fibroblast Diversity ; Skin Injury ; Skin Regeneration ; Wound Healing ; Wound Repair; Therapeutic Target; Heterogeneity; Distinct; Differentiation; Regeneration; Papillary; Identification; Subpopulation; Expression; Plasticity
ISSN (print) / ISBN 1664-3224
e-ISSN 1664-3224
Journal Frontiers in Immunology
Quellenangaben Volume: 14, Issue: , Pages: , Article Number: 1233800 Supplement: ,
Publisher Frontiers
Publishing Place Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Reviewing status Peer reviewed
Institute(s) Institute of Regenerative Biology and Medicine (IRBM)
Grants
European Foundation for the Study of Diabetes (EFSD) Anniversary Fund Programme
European Union
German Research Foundation
LEO Foundation
European Research Council
YR is funded by the European Research Council Consolidator Grant (ERC-CoG 819933), the LEO Foundation (LF-OC-21-000835), the German Research Foundation (SFB/TRR359 PILOT), the European Union Horizon 2020 (Marie Curie 955722 SkinTERM), and the European Fou