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Einfache Einteilung der Subtypen des Diabetes in der Praxis.Ein Kommentar.
Simple diabetes subtype classification in clinical practice: A commentary.
Diabetologie 19, 112-116 (2023)
Background: Diabetes mellitus is a complex disease with different pathophysiological causes. Research in recent years has described various pheno- and genotypically defined subgroups for both prediabetes and diabetes. Question: For everyday clinical practice, it is essential to recognize the different phenotypes. It is proposed to do this using a simple measurement of endogenous insulin secretion. Materials and methods: The fasting C‑peptide/glucose ratio (CGR) can be used to estimate endogenous insulin secretion. A prerequisite for this is preserved kidney function (GFR > 50 ml/min/1.73 m2). Results: Autoimmune diabetes and its subtypes can be recognized by a low C‑peptide/glucose ratio, representing a lack of endogenous insulin secretion. A low CGR also describes severe insulin-deficient diabetes (SIDD). In contrast, severe insulin-resistant diabetes (SIRD) is characterized by a high CGR, which is equivalent to insulin hypersecretion. Conclusion: The C‑peptide/glucose ratio allows a simple assessment of different pathophysiological forms of diabetes. Importantly, it can also provide additional information on the need for insulin therapy.
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Publication type
Article: Journal article
Document type
Review
Keywords
C‑peptide ; Diabetes Classification ; Glucose Metabolism Disorders ; Insulin Secretion ; Insulin, Therapy
ISSN (print) / ISBN
2731-7447
e-ISSN
2731-7455
Journal
Diabetologie, Die
Quellenangaben
Volume: 19,
Issue: 2,
Pages: 112-116
Publisher
Springer
Publishing Place
Tiergartenstrasse 17, D-69121 Heidelberg, Germany
Non-patent literature
Publications
Reviewing status
Peer reviewed