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Ainsbury, E.A.* ; Bakhanova, E.* ; Barquinero, J.F.* ; Brai, M.* ; Chumak, V.* ; Correcher, V.* ; Darroudi, F.* ; Fattibene, P.* ; Gruel, G.* ; Guclu, I.* ; Horn, S.* ; Jaworska, A.* ; Kulka, U.* ; Lindholm, C.* ; Lloyd, D.* ; Longo, A.* ; Marrale, M.* ; Monteiro Gil, O.* ; Oestreicher, U.* ; Pajic, J.* ; Rakic, B.* ; Romm, H.* ; Trompier, F.* ; Veronese, I.* ; Voisin, P.* ; Vral, A.* ; Whitehouse, C.A.* ; Wieser, A. ; Woda, C. ; Wojcik, A.* ; Rothkamm, K.*

Review of retrospective dosimetry techniques for external ionising radiation exposures.

Radiat. Prot. Dosim. 147, 573-592 (2011)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The current focus on networking and mutual assistance in the management of radiation accidents or incidents has demonstrated the importance of a joined-up approach in physical and biological dosimetry. To this end, the European Radiation Dosimetry Working Group 10 on 'Retrospective Dosimetry' has been set up by individuals from a wide range of disciplines across Europe. Here, established and emerging dosimetry methods are reviewed, which can be used immediately and retrospectively following external ionising radiation exposure. Endpoints and assays include dicentrics, translocations, premature chromosome condensation, micronuclei, somatic mutations, gene expression, electron paramagnetic resonance, thermoluminescence, optically stimulated luminescence, neutron activation, haematology, protein biomarkers and analytical dose reconstruction. Individual characteristics of these techniques, their limitations and potential for further development are reviewed, and their usefulness in specific exposure scenarios is discussed. Whilst no single technique fulfils the criteria of an ideal dosemeter, an integrated approach using multiple techniques tailored to the exposure scenario can cover most requirements.
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Publication type Article: Journal article
Document type Review
Keywords Optically stimulated luminescence; Gene-Expression profiles; Electron-paramagnetic-resonance; Peripheral-blood lymphocytes: Tooth enamel dosimetry; HPRT-mutant frequency; Accident dosimetry; Biological dosimetry; EPR spectrometry
Language english
Publication Year 2011
HGF-reported in Year 2011
ISSN (print) / ISBN 0144-8420
e-ISSN 1742-3406
Journal Radiation Protection Dosimetry
Quellenangaben Volume: 147, Issue: 4, Pages: 573-592 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Oxford
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Protection (ISS)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Radiation Sciences
PSP Element(s) G-501100-005
PubMed ID 21183550
DOI 10.1093/rpd/ncq499
Scopus ID 80052930413
Erfassungsdatum 2011-12-31
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