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Bunse, T. ; Körber, N. ; Wintersteller, H.* ; Schneider, J.* ; Graf, A.* ; Radonić, A.* ; Thuermer, A.* ; von Kleist, M.* ; Blum, H.* ; Spinner, C.D.* ; Bauer, T. ; Knolle, P.A.* ; Protzer, U. ; Schulte, E.C.

T-cell-dominated immune response resolves protracted SARS-CoV-2 infection in the absence of neutralizing antibodies in an immunocompromised individual.

Microorganisms 11:1562 (2023)
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Open Access Gold
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Immunocompromised individuals are at higher risk of developing protracted and severe COVID-19, and understanding individual disease courses and SARS-CoV-2 immune responses in these individuals is of the utmost importance. For more than two years, we followed an immunocompromised individual with a protracted SARS-CoV-2 infection that was eventually cleared in the absence of a humoral neutralizing SARS-CoV-2 antibody response. By conducting an in-depth examination of this individual’s immune response and comparing it to a large cohort of convalescents who spontaneously cleared a SARS-CoV-2 infection, we shed light on the interplay between B- and T-cell immunity and how they interact in clearing SARS-CoV-2 infection.
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Publication type Article: Journal article
Document type Scientific Article
Keywords B-and T-cell Immunity ; Immunocompromise ; Protracted Infection ; Sars-cov-2 ; Variants
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 2076-2607
e-ISSN 2076-2607
Journal Microorganisms
Quellenangaben Volume: 11, Issue: 6, Pages: , Article Number: 1562 Supplement: ,
Publisher MDPI
Publishing Place Basel
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Immune Response and Infection
PSP Element(s) G-502700-003
G-502700-002
G-502799-701
DOI 10.3390/microorganisms11061562
Scopus ID 85164105695
PubMed ID 37375064
Erfassungsdatum 2023-10-18
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