Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
T-cell-dominated immune response resolves protracted SARS-CoV-2 infection in the absence of neutralizing antibodies in an immunocompromised individual.
Microorganisms 11:1562 (2023)
Immunocompromised individuals are at higher risk of developing protracted and severe COVID-19, and understanding individual disease courses and SARS-CoV-2 immune responses in these individuals is of the utmost importance. For more than two years, we followed an immunocompromised individual with a protracted SARS-CoV-2 infection that was eventually cleared in the absence of a humoral neutralizing SARS-CoV-2 antibody response. By conducting an in-depth examination of this individual’s immune response and comparing it to a large cohort of convalescents who spontaneously cleared a SARS-CoV-2 infection, we shed light on the interplay between B- and T-cell immunity and how they interact in clearing SARS-CoV-2 infection.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
B-and T-cell Immunity ; Immunocompromise ; Protracted Infection ; Sars-cov-2 ; Variants
ISSN (print) / ISBN
2076-2607
e-ISSN
2076-2607
Journal
Microorganisms
Quellenangaben
Volume: 11,
Issue: 6,
Article Number: 1562
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)