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Hvidtfeldt, U.A.* ; Chen, J.* ; Rodopoulou, S.* ; Strak, M.* ; de Hoogh, K.* ; Andersen, Z.J.* ; Bellander, T.* ; Brandt, J.* ; Fecht, D.* ; Forastiere, F.* ; Gulliver, J.* ; Hertel, O.* ; Hoffmann, B.* ; Katsouyanni, K.* ; Ketzel, M.* ; Leander, K.* ; Magnusson, P.K.E.* ; Nagel, G.* ; Pershagen, G.* ; Rizzuto, D.* ; Samoli, E.* ; So, R.* ; Stafoggia, M.* ; Tjønneland, A.* ; Weinmayr, G.* ; Wolf, K. ; Zhang, J.* ; Zitt, E.* ; Brunekreef, B.* ; Hoek, G.* ; Raaschou-Nielsen, O.*

Long-term air pollution exposure and malignant intracranial tumours of the central nervous system: A pooled analysis of six European cohorts.

Br. J. Cancer 129, 656-664 (2023)
DOI PMC
Creative Commons Lizenzvertrag
Open Access Green as soon as Postprint is submitted to ZB.
Background: Risk factors for malignant tumours of the central nervous system (CNS) are largely unknown. Methods: We pooled six European cohorts (N = 302,493) and assessed the association between residential exposure to nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) and malignant intracranial CNS tumours defined according to the International Classification of Diseases ICD-9/ICD-10 codes 192.1/C70.0, 191.0–191.9/C71.0–C71.9, 192.0/C72.2–C72.5. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. Results: During 5,497,514 person-years of follow-up (average 18.2 years), we observed 623 malignant CNS tumours. The results of the fully adjusted linear analyses showed a hazard ratio (95% confidence interval) of 1.07 (0.95, 1.21) per 10 μg/m³ NO2, 1.17 (0.96, 1.41) per 5 μg/m³ PM2.5, 1.10 (0.97, 1.25) per 0.5 10−5m−1 BC, and 0.99 (0.84, 1.17) per 10 μg/m³ O3. Conclusions: We observed indications of an association between exposure to NO2, PM2.5, and BC and tumours of the CNS. The PM elements were not consistently associated with CNS tumour incidence.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Cancer; Risk; Men; Profile; Epidemiology; Completeness; Population; Models; Health; Women
ISSN (print) / ISBN 0007-0920
e-ISSN 1532-1827
Quellenangaben Volume: 129, Issue: 4, Pages: 656-664 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place Campus, 4 Crinan St, London, N1 9xw, England
Non-patent literature Publications
Reviewing status Peer reviewed
Grants United States Environmental Protection Agency (EPA)