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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Association between fatty liver index and blood coagulation markers: A population-based study.
Lipids Health Dis. 22:83 (2023)
Background: Population-based studies investigating the association between blood coagulation markers and non-alcoholic fatty liver disease (NAFLD) are rare. Thus, we aimed to investigate the relationship between the Fatty Liver Index (FLI) as a measure of hepatic steatosis and plasma concentrations of antithrombin III, D-dimer, fibrinogen D, protein C, protein S, factor VIII, activated partial thromboplastin time (aPTT), quick value and international thromboplastin time (INR) in the general population. Methods: After the exclusion of participants with anticoagulative treatment, 776 participants (420 women and 356 men, aged 54–74 years) of the population-based KORA Fit study with analytic data on hemostatic factors were included in the present analysis. Linear regression models were used to explore the associations between FLI and hemostatic markers, adjusted for sex, age, alcohol consumption, education, smoking status, and physical activity. In a second model, additional adjustments were made for the history of stroke, hypertension, myocardial infarction, serum non-HDL cholesterol levels, and diabetes status. In addition, analyses were stratified by diabetes status. Results: In the multivariable models (with or without health conditions), significantly positive associations with FLI were obtained for plasma concentrations of D-dimers, factor VIII, fibrinogen D, protein C, protein S, and quick value, while INR and antithrombin III were inversely associated. These associations were weaker in pre-diabetic subjects and largely disappeared in diabetic patients. Conclusion: In this population-based study, an increased FLI is clearly related to changes in the blood coagulation system, possibly increasing the risk of thrombotic events. Due to a generally more pro-coagulative profile of hemostatic factors, such an association is not visible in diabetic subjects.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Coagulation ; Fatty Liver Index ; Hemostatic Factors ; Hepatic Steatosis ; Kora; Partial Thromboplastin Time; D-dimer; Factor-viii; Disease; Protein; Management; Risk
ISSN (print) / ISBN
1476-511X
e-ISSN
1476-511X
Journal
Lipids in Health and Disease
Quellenangaben
Volume: 22,
Issue: 1,
Article Number: 83
Publisher
Springer
Publishing Place
Campus, 4 Crinan St, London N1 9xw, England
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology II (EPI2)