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Liu, X.* ; Johnson, S.B.* ; Lynch, K.F.* ; Cordan, K.* ; Pate, R.* ; Butterworth, M.D.* ; Lernmark, Å.* ; Hagopian, W.A.* ; Rewers, M.J.* ; McIndoe, R.A.* ; Toppari, J.* ; Ziegler, A.-G. ; Akolkar, B.* ; Krischer, J.P.* ; Yang, J.*

Physical activity and the development of islet autoimmunity and type 1 diabetes in 5-to 15-year-old children followed in the TEDDY study.

Diabetes Care 46, 1409-1416 (2023)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
OBJECTIVE This study investigated physical activity and its association with the development of islet autoimmunity and type 1 diabetes in genetically at-risk children aged 5–15 years. RESEARCH DESIGN AND METHODS As part of the longitudinal Environmental Determinants of Diabetes in the Young (TEDDY) study, annual assessment of activity using accelerometry was conducted from age 5 years. Time-to-event analyses using Cox proportional hazard models were used to assess the association between time spent in moderate to vigorous physical activity per day and the appearance of one or several autoantibodies and progression to type 1 diabetes in three risk groups: 1) 3,869 islet autoantibody (IA)-negative children, of whom 157 became single IA positive; 2) 302 single IA–positive children, of whom 73 became multiple IA positive; and 3) 294 multiple IA–positive children, of whom 148 developed type 1 diabetes. RESULTS No significant association was found in risk group 1 or risk group 2. A significant association was seen in risk group 3 (hazard ratio 0.920 [95% CI 0.856, 0.988] per 10-min increase; P = 0.021), particularly when glutamate decarboxylase autoantibody was the first autoantibody (hazard ratio 0.883 [95% CI 0.783, 0.996] per 10-min increase; P = 0.043). CONCLUSIONS More daily minutes spent in moderate to vigorous physical activity was associated with a reduced risk of progression to type 1 diabetes in children aged 5–15 years who had developed multiple IAs.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Multiple Autoantibodies; Insulin-resistance; Excess Bmi; Exercise; Risk; Association; Childhood; Metaanalysis; Progression; Regions
ISSN (print) / ISBN 0149-5992
e-ISSN 1935-5548
Journal Diabetes Care
Quellenangaben Volume: 46, Issue: 7, Pages: 1409-1416 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, Va.
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research Type 1 (IDF)
Grants National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Allergy and Infectious Diseases
Eunice Kennedy Shriver National Institute of Child Health and Human Development
JDRF
National Center for Advancing Translational Sciences of the National Institutes of Health
University of Colorado
National Institute of Environmental Health Sciences, Centers for Disease Control and Prevention

National Institutes of Health