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Jacob, C.* ; Olliges, E.* ; Haile, A.* ; Hoffmann, V.* ; Jacobi, B.* ; Steinkopf, L.* ; Lanz, M.* ; Wittmann, M.* ; Tschöp, M.H. ; Meissner, K.*

Placebo effects on nausea and motion sickness are resistant to experimentally-induced stress.

Sci. Rep. 13:9908 (2023)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Nausea often occurs in stressful situations, such as chemotherapy or surgery. Clinically relevant placebo effects in nausea have been demonstrated, but it remains unclear whether stress has an impact on these effects. The aim of this experimental study was to investigate the interplay between acute stress and placebo effects in nausea. 80 healthy female volunteers susceptible to motion sickness were randomly assigned to either the Maastricht Acute Stress Test or a non-stress control condition, and to either placebo treatment or no treatment. Nausea was induced by a virtual vection drum and behavioral, psychophysiological as well as humoral parameters were repeatedly assessed. Manipulation checks confirmed increased cortisol levels and negative emotions in the stressed groups. In the non-stressed groups, the placebo intervention improved nausea, symptoms of motion sickness, and gastric myoelectrical activity (normo-to-tachy (NTT) ratio). In the stressed groups, the beneficial effects of the placebo intervention on nausea and motion sickness remained unchanged, whereas no improvement of the gastric NTT ratio was observed. Results suggest that placebo effects on symptoms of nausea and motion sickness are resistant to experimentally-induced stress. Stress most likely interfered with the validity of the gastric NTT ratio to measure nausea and thus the gastric placebo effect.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Gastric Myoelectrical Activity; Visually Induced Nausea; Hospital Anxiety; Intervention; Time; Acupuncture; Instruction; Responses; Tone
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Journal Scientific Reports
Quellenangaben Volume: 13, Issue: 1, Pages: , Article Number: 9908 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
Grants Projekt DEAL
German Research Foundation (DFG)