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Han, Y. ; Georgii, E. ; Priego-Cubero, S.* ; Wurm, C. ; Hüther, P.* ; Huber, G.* ; Koller, R.* ; Becker, C.* ; Durner, J. ; Lindermayr, C.

Arabidopsis histone deacetylase HD2A and HD2B regulate seed dormancy by repressing DELAY OF GERMINATION 1.

Front. Plant Sci. 14:1124899 (2023)

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Seed dormancy is a crucial developmental transition that affects the adaption and survival of plants. Arabidopsis DELAY OF GERMINATION 1 (DOG1) is known as a master regulator of seed dormancy. However, although several upstream factors of DOG1 have been reported, the exact regulation of DOG1 is not fully understood. Histone acetylation is an important regulatory layer, controlled by histone acetyltransferases and histone deacetylases. Histone acetylation strongly correlates with transcriptionally active chromatin, whereas heterochromatin is generally characterized by hypoacetylated histones. Here we describe that loss of function of two plant-specific histone deacetylases, HD2A and HD2B, resulted in enhanced seed dormancy in Arabidopsis. Interestingly, the silencing of HD2A and HD2B caused hyperacetylation of the DOG1 locus and promoted the expression of DOG1 during seed maturation and imbibition. Knockout of DOG1 could rescue the seed dormancy and partly rescue the disturbed development phenotype of hd2ahd2b. Transcriptomic analysis of the hd2ahd2b line shows that many genes involved in seed development were impaired. Moreover, we demonstrated that HSI2 and HSL1 interact with HD2A and HD2B. In sum, these results suggest that HSI2 and HSL1 might recruit HD2A and HD2B to DOG1 to negatively regulate DOG1 expression and to reduce seed dormancy, consequently, affecting seed development during seed maturation and promoting seed germination during imbibition.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Arabidopsis Thaliana ; Delay Of Germination 1 ; Histone Acetylation ; Plant-specific Histone Deacetylases ; Seed Dormancy ; Seed Germination; Gene-expression; Interacts; Dog1; Hda6; Acetylation; Inhibition; Mechanism; Release; Assay; Time

ISSN (print) / ISBN 1664-462X

e-ISSN 1664-462X

Journal Frontiers in Plant Science

Quellenangaben Volume: 14, Article Number: 1124899

Publisher Frontiers

Publishing Place Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Biochemical Plant Pathology (BIOP)
Institute of Lung Biology (LHI)

Grants Helmholtz-Partnership for Plant Sciences (HP-PS)
Bundesministerium fuer Bildung und Forschung (BMBF)