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Aging and regeneration in the lung – Significance for COPD.
Atemwegs- Lungenkr. 49, 140-146 (2023)
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Lung transplantation remains the only curative option for patients with end-stage disease. A missing understanding of pathomechanisms and phenotypes of COPD hampers the development of novel therapeutic approaches. COPD is a disease of the aging population and is characterized by impaired regenerative capacity of the lung. Regenerative capacity is reduced in the aging lung which is caused by different cellular processes. Among those, cellular senescence is a main mechanism which is increased in COPD lungs. Cellular senescence impairs stem cell capacity and contributes to aging-associated chronic inflammation, so-called inflammaging. The therapeutic targeting of cellular senescence showed first promising results in preclinical experiments and suggests cellular senescence as a main target for personalized medicine approaches aiming at restoring the regenerative capacity of the COPD lung.
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Publication type
Article: Journal article
Document type
Review
Keywords
Aging ; Cellular Senescence ; Copd ; Regeneration ; Senolytics
ISSN (print) / ISBN
0341-3055
e-ISSN
0341-3055
Journal
Atemwegs- und Lungenkrankheiten
Quellenangaben
Volume: 49,
Issue: 4,
Pages: 140-146
Publisher
Dustri
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Lung Health and Immunity (LHI)