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Taheri, M.H.* ; Askari, N.* ; Feng, Y.* ; Nabaei, M.* ; Islam, M.S.* ; Farnoud, A. ; Cui, X.*

Swirling flow and capillary diameter effect on the performance of an active dry powder inhalers.

Med. Nov. Techn. Dev. 18:100240 (2023)
Publ. Version/Full Text DOI
For patients with lung disease, dry powder inhalers (DPI) are profoundly beneficial. The current study introduces and develops a series of dry powder inhalers (DPIs). A capsule-based (size 0) active DPI was considered. The study aims to investigate whether swirling flow and outlet capillary diameter (dc_out) affect the percentage of emitted doses (ED) released from the capsule. Spiral vanes were added to the capillary inlet to produce a swirling flow. Computational fluid dynamics (CFD) was applied to simulate the problem. The results were compared with previous in vitro and numerical studies to validate the results. Based on the derived results, the small swirl parameter (SP) enhances the secondary flow and recirculation zone. It increases the central jet flow, which increases the ED value by about 5–20% compared to no-swirl flow. However, as the airflow rate increases, the recirculation zone enlarges, vorticities become dominant, and asymmetrical flow patterns emerge. Consequently, ED % drops significantly (more than 50%). As dc_out decreases, the vorticities around the outlet capillary become more potent, which is undesirable. Indeed, the emptying of the capsule does not happen ideally. The research provides a perspective on the device's design and DPI performance.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Computational Fluid Dynamics ; Dry Powder Inhalers ; Swirling Flow
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 2590-0935
e-ISSN 2590-0935
Journal Medicine in Novel Technology and Devices
Quellenangaben Volume: 18, Issue: , Pages: , Article Number: 100240 Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-554700-001
DOI 10.1016/j.medntd.2023.100240
Scopus ID 85160296925
Erfassungsdatum 2023-12-08
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