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Kurmi, B.D.* ; Patel, P.* ; Paliwal, R.* ; Kumar, P. ; Paliwal, S.R.*

Multifunctional nanotherapeutics for intracellular trafficking of doxorubicin against breast cancer.

Nanomed. 18, 1261-1279 (2023)

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Aims: To develop an estrone-targeted d-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS)-based liposomal system for enhanced intracellular delivery of doxorubicin (DOX). Materials & methods: Zetasizer, transmission electron microscopy, energy dispersive x-ray, Fourier-transform infrared spectroscopy, differential scanning calorimetry, x-ray diffraction, confocal laser scanning microscopy and FACS analysis were used for formulation characterization and evaluation. Results: The DOX-LIPO-TPGS and DOX-LIPO-TPGS-estrone formulations had vesicle sizes (117.6 ± 3.51; 144 ± 5.00 nm), zeta potential (-36.4 ± 0.75; -35.8 ± 0.76), polydispersity index (0.123 ± 0.005; 0.169 ± 0.005) and percent entrapment efficiency (73.56 ± 3.55; 77.16 ± 3.83%) with improved cytotoxicity and cellular uptake, confirming the targeted potential of the developed formulations. Conclusion: The results suggest that the developed liposomal formulation with desired characteristics is potentially capable of nonimmunogenic, site-specific drug delivery to targeted cancer sites and reduced DOX-associated cardiac toxicity.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Tpgs ; Breast Cancer ; Doxorubicin ; Estrogen Receptor ; Liposome; Vitamin-e Tpgs; In-vitro Characterization; Liposomal Doxorubicin; Targeted Delivery; Stability; Nanoparticles; Paclitaxel; Micelles; Release; Nanocarriers

ISSN (print) / ISBN 1743-5889

e-ISSN 1748-6963

Journal Nanomedicine

Quellenangaben Volume: 18, Issue: 19, Pages: 1261-1279

Publisher Future Medicine

Publishing Place Unitec House, 3rd Floor, 2 Albert Place, Finchley Central, London, N3 1qb, England

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Lung Health and Immunity (LHI)

Grants Science and Engineering Research Board, Department of Science and Technology, New Delhi
Council of Scientific & Industrial Research (CSIR) New Delhi