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Kurmi, B.D.* ; Patel, P.* ; Paliwal, R.* ; Kumar, P. ; Paliwal, S.R.*

Multifunctional nanotherapeutics for intracellular trafficking of doxorubicin against breast cancer.

Nanomed. 18, 1261-1279 (2023)
DOI PMC
Aims: To develop an estrone-targeted d-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS)-based liposomal system for enhanced intracellular delivery of doxorubicin (DOX). Materials & methods: Zetasizer, transmission electron microscopy, energy dispersive x-ray, Fourier-transform infrared spectroscopy, differential scanning calorimetry, x-ray diffraction, confocal laser scanning microscopy and FACS analysis were used for formulation characterization and evaluation. Results: The DOX-LIPO-TPGS and DOX-LIPO-TPGS-estrone formulations had vesicle sizes (117.6 ± 3.51; 144 ± 5.00 nm), zeta potential (-36.4 ± 0.75; -35.8 ± 0.76), polydispersity index (0.123 ± 0.005; 0.169 ± 0.005) and percent entrapment efficiency (73.56 ± 3.55; 77.16 ± 3.83%) with improved cytotoxicity and cellular uptake, confirming the targeted potential of the developed formulations. Conclusion: The results suggest that the developed liposomal formulation with desired characteristics is potentially capable of nonimmunogenic, site-specific drug delivery to targeted cancer sites and reduced DOX-associated cardiac toxicity.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Tpgs ; Breast Cancer ; Doxorubicin ; Estrogen Receptor ; Liposome; Vitamin-e Tpgs; In-vitro Characterization; Liposomal Doxorubicin; Targeted Delivery; Stability; Nanoparticles; Paclitaxel; Micelles; Release; Nanocarriers
ISSN (print) / ISBN 1743-5889
e-ISSN 1748-6963
Journal Nanomedicine
Quellenangaben Volume: 18, Issue: 19, Pages: 1261-1279 Article Number: , Supplement: ,
Publisher Future Medicine
Publishing Place Unitec House, 3rd Floor, 2 Albert Place, Finchley Central, London, N3 1qb, England
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
Grants Science and Engineering Research Board, Department of Science and Technology, New Delhi
Council of Scientific & Industrial Research (CSIR) New Delhi