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Stafoggia, M.* ; Michelozzi, P.* ; Schneider, A.E. ; Armstrong, B.* ; Scortichini, M.* ; Rai, M. ; Achilleos, S.* ; Alahmad, B.* ; Analitis, A.* ; Åström, C.* ; Bell, M.L.* ; Calleja, N.* ; Krage Carlsen, H.* ; Carrasco, G.* ; Paul Cauchi, J.* ; Dszs Coelho, M.* ; Correa, P.M.* ; Diaz, M.H.* ; Entezari, A.* ; Forsberg, B.* ; Garland, R.M.* ; Leon Guo, Y.* ; Guo, Y.* ; Hashizume, M.* ; Holobaca, I.H.* ; Iñiguez, C.* ; Jaakkola, J.J.K.* ; Kan, H.* ; Katsouyanni, K.* ; Kim, H.* ; Kyselý, J.* ; Lavigne, E.* ; Lee, W.* ; Li, S.* ; Maasikmets, M.* ; Madureira, J.* ; Mayvaneh, F.* ; Fook Sheng Ng, C.* ; Nunes, B.* ; Orru, H.* ; V Ortega, N.* ; Osorio, S.* ; Palomares, A.D.L.* ; Pan, S.C.* ; Pascal, M.* ; Ragettli, M.S.* ; Rao, S.* ; Raz, R.* ; Royé, D.* ; Ryti, N.* ; Hn Saldiva, P.* ; Samoli, E.* ; Schwartz, J.* ; Scovronick, N.* ; Sera, F.* ; Tobias, A.* ; Tong, S.* ; Dlc Valencia, C.* ; Maria Vicedo-Cabrera, A.* ; Urban, A.* ; Gasparrini, A.* ; Breitner, S.* ; De' Donato, F.K.*

Joint effect of heat and air pollution on mortality in 620 cities of 36 countries.

Environ. Int. 181:108258 (2023)
Postprint DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
BACKGROUND: The epidemiological evidence on the interaction between heat and ambient air pollution on mortality is still inconsistent. OBJECTIVES: To investigate the interaction between heat and ambient air pollution on daily mortality in a large dataset of 620 cities from 36 countries. METHODS: We used daily data on all-cause mortality, air temperature, particulate matter ≤ 10 μm (PM10), PM ≤ 2.5 μm (PM2.5), nitrogen dioxide (NO2), and ozone (O3) from 620 cities in 36 countries in the period 1995-2020. We restricted the analysis to the six consecutive warmest months in each city. City-specific data were analysed with over-dispersed Poisson regression models, followed by a multilevel random-effects meta-analysis. The joint association between air temperature and air pollutants was modelled with product terms between non-linear functions for air temperature and linear functions for air pollutants. RESULTS: We analyzed 22,630,598 deaths. An increase in mean temperature from the 75th to the 99th percentile of city-specific distributions was associated with an average 8.9 % (95 % confidence interval: 7.1 %, 10.7 %) mortality increment, ranging between 5.3 % (3.8 %, 6.9 %) and 12.8 % (8.7 %, 17.0 %), when daily PM10 was equal to 10 or 90 μg/m3, respectively. Corresponding estimates when daily O3 concentrations were 40 or 160 μg/m3 were 2.9 % (1.1 %, 4.7 %) and 12.5 % (6.9 %, 18.5 %), respectively. Similarly, a 10 μg/m3 increment in PM10 was associated with a 0.54 % (0.10 %, 0.98 %) and 1.21 % (0.69 %, 1.72 %) increase in mortality when daily air temperature was set to the 1st and 99th city-specific percentiles, respectively. Corresponding mortality estimate for O3 across these temperature percentiles were 0.00 % (-0.44 %, 0.44 %) and 0.53 % (0.38 %, 0.68 %). Similar effect modification results, although slightly weaker, were found for PM2.5 and NO2. CONCLUSIONS: Suggestive evidence of effect modification between air temperature and air pollutants on mortality during the warm period was found in a global dataset of 620 cities.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Air Pollution ; Air Temperature ; Effect Modification ; Epidemiology ; Mortality; Ozone-related Mortality; Cardiovascular Mortality; Ambient-temperature; Associations; Waves
ISSN (print) / ISBN 0160-4120
e-ISSN 1873-6750
Quellenangaben Volume: 181, Issue: , Pages: , Article Number: 108258 Supplement: ,
Publisher Elsevier
Publishing Place The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Non-patent literature Publications
Reviewing status Peer reviewed
Grants Natural Environment Research Council UK
Medical Research Council-UK
NIEHS-funded HERCULES Center
Japan Science and Technology Agency (JST)
Fundacao para a Ciencia e a Tecnologia (FCT)
Czech Science Foundation project
European Union