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Kühnel, A.* ; Hagenberg, J. ; Knauer-Arloth, J. ; Ködel, M.* ; Czisch, M.* ; Sämann, P.G.* ; Binder, E.B.* ; Kroemer, N.B.*

Stress-induced brain responses are associated with BMI in women.

Comm. Biol. 6:1031 (2023)
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Overweight and obesity are associated with altered stress reactivity and increased inflammation. However, it is not known whether stress-induced changes in brain function scale with BMI and if such associations are driven by peripheral cytokines. Here, we investigate multimodal stress responses in a large transdiagnostic sample using predictive modeling based on spatio-temporal profiles of stress-induced changes in activation and functional connectivity. BMI is associated with increased brain responses as well as greater negative affect after stress and individual response profiles are associated with BMI in females (pperm < 0.001), but not males. Although stress-induced changes reflecting BMI are associated with baseline cortisol, there is no robust association with peripheral cytokines. To conclude, alterations in body weight and energy metabolism might scale acute brain responses to stress more strongly in females compared to males, echoing observational studies. Our findings highlight sex-dependent associations of stress with differences in endocrine markers, largely independent of peripheral inflammation.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Acute Psychosocial Stress; Body-mass Index; Sex-differences; Functional Connectivity; Gender-differences; Metabolic-syndrome; Limbic System; Hpa-axis; Obesity; Cortisol
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 2399-3642
e-ISSN 2399-3642
Journal Communications Biology
Quellenangaben Volume: 6, Issue: 1, Pages: , Article Number: 1031 Supplement: ,
Publisher Springer
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-503800-001
Grants Brain Behaviour Research Foundation (NARSAD Young Investigator Grant)
Deutsche Forschungsgemeinschaft (DFG)
DOI 10.1038/s42003-023-05396-8
WOS ID 001115932000001
Scopus ID 85173804423
PubMed ID 37821711
Erfassungsdatum 2023-11-28
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