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Keller, M. ; Svensson, S.I.A.* ; Rohde-Zimmermann, K. ; Kovacs, P.* ; Böttcher, Y.*

Genetics and epigenetics in obesity: What do we know so far?

Curr. Obes. Rep. 12, 482-501 (2023)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
PURPOSE OF REVIEW: Enormous progress has been made in understanding the genetic architecture of obesity and the correlation of epigenetic marks with obesity and related traits. This review highlights current research and its challenges in genetics and epigenetics of obesity. RECENT FINDINGS: Recent progress in genetics of polygenic traits, particularly represented by genome-wide association studies, led to the discovery of hundreds of genetic variants associated with obesity, which allows constructing polygenic risk scores (PGS). In addition, epigenome-wide association studies helped identifying novel targets and methylation sites being important in the pathophysiology of obesity and which are essential for the generation of methylation risk scores (MRS). Despite their great potential for predicting the individual risk for obesity, the use of PGS and MRS remains challenging. Future research will likely discover more loci being involved in obesity, which will contribute to better understanding of the complex etiology of human obesity. The ultimate goal from a clinical perspective will be generating highly robust and accurate prediction scores allowing clinicians to predict obesity as well as individual responses to body weight loss-specific life-style interventions.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Epigenetic Marks ; Genetic Variants ; Methylation Risk Scores ; Obesity ; Polygenic Risk Scores; Body-mass Index; Epigenome-wide Association; Analysis Identifies Common; Dna Methylation Markers; Visceral Adipose-tissue; Fatty-acid Oxidation; Childhood Obesity; Cholesterol Efflux; Men Discordant; Adult Obesity
ISSN (print) / ISBN 2162-4968
e-ISSN 2162-4968
Journal Current Obesity Reports
Quellenangaben Volume: 12, Issue: 4, Pages: 482-501 Article Number: , Supplement: ,
Publisher Springer
Publishing Place One New York Plaza, Suite 4600, New York, Ny, United States
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Grants University of Oslo (incl Oslo University Hospital)