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Multi-species atlas resolves an axolotl limb development and regeneration paradox.
Nat. Commun. 14:6346 (2023)
Humans and other tetrapods are considered to require apical-ectodermal-ridge (AER) cells for limb development, and AER-like cells are suggested to be re-formed to initiate limb regeneration. Paradoxically, the presence of AER in the axolotl, a primary model organism for regeneration, remains controversial. Here, by leveraging a single-cell transcriptomics-based multi-species atlas, composed of axolotl, human, mouse, chicken, and frog cells, we first establish that axolotls contain cells with AER characteristics. Further analyses and spatial transcriptomics reveal that axolotl limbs do not fully re-form AER cells during regeneration. Moreover, the axolotl mesoderm displays part of the AER machinery, revealing a program for limb (re)growth. These results clarify the debate about the axolotl AER and the extent to which the limb developmental program is recapitulated during regeneration.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Expression Patterns; Cell-proliferation; Gene-expression; Epidermal Cap; Amputation; Inhibition; Urodele; Origin
ISSN (print) / ISBN
2041-1723
e-ISSN
2041-1723
Journal
Nature Communications
Quellenangaben
Volume: 14,
Issue: 1,
Article Number: 6346
Publisher
Nature Publishing Group
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)
Grants
Von Humboldt Foundation Research fellowship
SNSF
Foundation Gabriella Giorgi-Cavaglieri, Branco Weiss Fellowship
A. Petzold and the CM
M. Ros, D. Suter, G. La Manno, and M. Gurel for their critical reading of the manuscript
M. Gurel and M. Brbic for discussions on factorization and module identification
We thank Aztekin and Sandoval-Guzman Labs for the discussions
SNSF
Foundation Gabriella Giorgi-Cavaglieri, Branco Weiss Fellowship
A. Petzold and the CM
M. Ros, D. Suter, G. La Manno, and M. Gurel for their critical reading of the manuscript
M. Gurel and M. Brbic for discussions on factorization and module identification
We thank Aztekin and Sandoval-Guzman Labs for the discussions