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Composition of gut microbiota and non-alcoholic fatty liver disease: A systematic review and meta-analysis.
Obes. Rev. 25:e13646 (2024)
The present systematic review and meta-analysis aimed to summarize the associations between gut microbiota composition and non-alcoholic fatty liver disease. To compare the differences between individuals with or without NAFLD, the standardized mean difference and 95% confidence interval were computed for each α-diversity index and relative abundance of gut microbes. The β-diversity indices were summarized in a qualitative manner. A total of 54 studies with 8894 participants were included. Overall, patients with NAFLD had moderate reduction in α-diversity indices including Shannon (SMD = -0.36, 95% CI = [-0.53, -0.19], p < 0.001) and Chao 1 (SMD = -0.42, 95% CI = [-0.68, -0.17], p = 0.001), but no significant differences were found for Simpson, observed species, phylogenetic diversity, richness, abundance-based coverage estimator, and evenness (p ranged from 0.081 to 0.953). Over 75% of the included studies reported significant differences in β-diversity. Although there was substantial interstudy heterogeneity, especially for analyses at the phylum, class, and family levels, the majority of the included studies showed alterations in the depletion of anti-inflammatory microbes (i.e., Ruminococcaceae and Coprococcus) and the enrichment of proinflammatory microbes (i.e., Fusobacterium and Escherichia) in patients with NAFLD. Perturbations in gut microbiota were associated with NAFLD, commonly reflected by a reduction in beneficial species and an increase in the pathogenic species.
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Publication type
Article: Journal article
Document type
Review
Keywords
Gut Microbiota ; Meta-analysis ; Non-alcoholic Fatty Liver ; Systematic Review; Fusobacterium-nucleatum; Fecal Microbiota; Receptor; Steatohepatitis; Inflammation; Dysbiosis; Butyrate; Ethanol; Obesity; Il-17
ISSN (print) / ISBN
1467-7881
e-ISSN
1467-789X
Journal
Obesity Reviews
Quellenangaben
Volume: 25,
Issue: 1,
Article Number: e13646
Publisher
Blackwell
Publishing Place
Oxford
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology II (EPI2)
Grants
National Natural Science Foundation of China
Guangdong Basic and Applied Basic Research Foundation
This research was supported by grants from Guangdong Basic and Applied Basic Research Foundation (2023A1515030155, Z.F.F.) and National Natural Science Foundation of China (81602853, Z.F.F.).
Guangdong Basic and Applied Basic Research Foundation
This research was supported by grants from Guangdong Basic and Applied Basic Research Foundation (2023A1515030155, Z.F.F.) and National Natural Science Foundation of China (81602853, Z.F.F.).