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Role of cell-based therapies in T2D.
Semin. Nephrol. 43:151432 (2023)
Type 2 diabetes mellitus (T2D) has become a global epidemic affecting the health of millions of people. T2D is a complex and multifactorial metabolic disease, largely characterized by a combination of impaired insulin secretion from β cells residing within the islets of the pancreas and peripheral insulin resistance. In this article, we discuss the current state and risk factors for T2D, conventional treatment options, and upcoming strategies, including progress in the areas of allogeneic and xenogeneic islet transplantation, with a major focus on stem cell-derived β cells and associated technologies.
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Publication type
Article: Journal article
Document type
Review
Keywords
T(reg) Therapy ; Type 2 Diabetes Mellitus ; Clinical Trials ; Immune Modulation ; Stem Cell Therapy ; β Cells; Beta-cells; Pancreatic Progenitors; Maturation; Challenges; Generation; Reversal
ISSN (print) / ISBN
0270-9295
Journal
Seminars in Nephrology
Quellenangaben
Volume: 43,
Issue: 3,
Article Number: 151432
Publisher
Elsevier
Publishing Place
Philadelphia
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Diabetes und Organoid Technology (IDOT)
Grants
Juvenile Diabetes Research Foundation-JDRF
National Institutes of Health
Bayer Corporation
National Institutes of Health
Bayer Corporation