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Ashe, S.* ; Hebrok, M.

Role of cell-based therapies in T2D.

Semin. Nephrol. 43:151432 (2023)
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Type 2 diabetes mellitus (T2D) has become a global epidemic affecting the health of millions of people. T2D is a complex and multifactorial metabolic disease, largely characterized by a combination of impaired insulin secretion from β cells residing within the islets of the pancreas and peripheral insulin resistance. In this article, we discuss the current state and risk factors for T2D, conventional treatment options, and upcoming strategies, including progress in the areas of allogeneic and xenogeneic islet transplantation, with a major focus on stem cell-derived β cells and associated technologies.
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Publication type Article: Journal article
Document type Review
Keywords T(reg) Therapy ; Type 2 Diabetes Mellitus ; Clinical Trials ; Immune Modulation ; Stem Cell Therapy ; β Cells; Beta-cells; Pancreatic Progenitors; Maturation; Challenges; Generation; Reversal
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 0270-9295
Quellenangaben Volume: 43, Issue: 3, Pages: , Article Number: 151432 Supplement: ,
Publisher Elsevier
Publishing Place Philadelphia
Reviewing status Peer reviewed
Institute(s) Institute for Diabetes und Organoid Technology (IDOT)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-509600-001
Grants Juvenile Diabetes Research Foundation-JDRF
National Institutes of Health
Bayer Corporation
Scopus ID 85175251441
PubMed ID 37918206
Erfassungsdatum 2023-11-28