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Epigenomic profiling of the infrapatellar fat pad in osteoarthritis.
Hum. Mol. Genet. 33:ddad198 (2023)
Osteoarthritis is a prevalent, complex disease of the joints, and affects multiple intra-articular tissues. Here, we have examined genome-wide DNA methylation profiles of primary infrapatellar fat pad and matched blood samples from 70 osteoarthritis patients undergoing total knee replacement surgery. Comparing the DNA methylation profiles between these tissues reveal widespread epigenetic differences. We produce the first genome-wide methylation quantitative trait locus (mQTL) map of fat pad, and make the resource available to the wider community. Using two-sample Mendelian randomization and colocalization analyses, we resolve osteoarthritis GWAS signals and provide insights into the molecular mechanisms underpinning disease aetiopathology. Our findings provide the first view of the epigenetic landscape of infrapatellar fat pad primary tissue in osteoarthritis.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Dna Methylation ; Ewas ; Infrapatellar Fat Pad ; Methylation Qtl ; Osteoarthritis; Knee Osteoarthritis; Synoviocytes; Expression; Package; Disease; Tissue; Power
Language
english
Publication Year
2023
HGF-reported in Year
2023
ISSN (print) / ISBN
0964-6906
e-ISSN
1460-2083
Journal
Human Molecular Genetics
Quellenangaben
Volume: 33,
Issue: 6,
Article Number: ddad198
Publisher
Oxford University Press
Publishing Place
Great Clarendon St, Oxford Ox2 6dp, England
Reviewing status
Peer reviewed
Institute(s)
Institute of Translational Genomics (ITG)
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-506700-001
Grants
Wellcome Trust
WOS ID
001112500000001
Scopus ID
85186680140
PubMed ID
37975894
Erfassungsdatum
2023-11-28