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Correa-Gallegos, D. ; Ye, H. ; Dasgupta, B. ; Sardogan, A. ; Kadri, S. ; Kandi, R. ; Dai, R. ; Lin, Y. ; Kopplin, R. ; Shantaram Shenai, D. ; Wannemacher, J. ; Ichijo, R. ; Jiang, D. ; Strunz, M. ; Ansari, M. ; Angelidis, I. ; Schiller, H. ; Voltz, T.* ; Machens, H.G.* ; Rinkevich, Y.

CD201+ fascia progenitors choreograph injury repair.

Nature 623, 792-802 (2023)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Optimal tissue recovery and organismal survival are achieved by spatiotemporal tuning of tissue inflammation, contraction and scar formation1. Here we identify a multipotent fibroblast progenitor marked by CD201 expression in the fascia, the deepest connective tissue layer of the skin. Using skin injury models in mice, single-cell transcriptomics and genetic lineage tracing, ablation and gene deletion models, we demonstrate that CD201+ progenitors control the pace of wound healing by generating multiple specialized cell types, from proinflammatory fibroblasts to myofibroblasts, in a spatiotemporally tuned sequence. We identified retinoic acid and hypoxia signalling as the entry checkpoints into proinflammatory and myofibroblast states. Modulating CD201+ progenitor differentiation impaired the spatiotemporal appearances of fibroblasts and chronically delayed wound healing. The discovery of proinflammatory and myofibroblast progenitors and their differentiation pathways provide a new roadmap to understand and clinically treat impaired wound healing.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Dermal Fibroblasts; Hypoxia; Skin; Transition; Cells; Differentiation; Fibrosis
ISSN (print) / ISBN 0028-0836
e-ISSN 1476-4687
Journal Nature
Quellenangaben Volume: 623, Issue: 7988, Pages: 792-802 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Regenerative Biology and Medicine (IRBM)
German Center for Lung Research (DZL)
Institute of Lung Health and Immunity (LHI)
Grants European Foundation for the Study of Diabetes (EFSD) Anniversary Fund Program
LEO Foundation
European Research Council