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de Las Fuentes, L.* ; Schwander, K.L.* ; Brown, M.R.* ; Bentley, A.R.* ; Winkler, T.W.* ; Sung, Y.J.* ; Munroe, P.B.* ; Miller, C.L.* ; Aschard, H.* ; Aslibekyan, S.* ; Bartz, T.M.* ; Bielak, L.F.* ; Chai, J.F.* ; Cheng, C.Y.* ; Dorajoo, R.* ; Feitosa, M.F.* ; Guo, X.* ; Hartwig, F.P.* ; Horimoto, A.R.* ; Kolcic, I.* ; Lim, E.* ; Liu, Y.* ; Manning, A.K.* ; Marten, J.* ; Musani, S.K.* ; Noordam, R.* ; Padmanabhan, S.* ; Rankinen, T.* ; Richard, M.A.* ; Ridker, P.M.* ; Smith, A.V.* ; Vojinovic, D.* ; Zonderman, A.B.* ; Alver, M.* ; Boissel, M.* ; Christensen, K.* ; Freedman, B.I.* ; Gao, C.* ; Giulianini, F.* ; Harris, S.E.* ; He, M.* ; Hsu, F.C.* ; Kühnel, B. ; Laguzzi, F.* ; Li, X.* ; Lyytikäinen, L.P.* ; Nolte, I.M.* ; Poveda, A.* ; Rauramaa, R.* ; Riaz, M.* ; Robino, A.* ; Sofer, T.* ; Takeuchi, F.* ; Tayo, B.O.* ; van der Most, P.J.* ; Verweij, N.* ; Ware, E.B.* ; Weiss, S.* ; Wen, W.* ; Yanek, L.R.* ; Zhan, Y.* ; Amin, N.* ; Arking, D.E.* ; Ballantyne, C.* ; Boerwinkle, E.* ; Brody, J.A.* ; Broeckel, U.* ; Campbell, A.* ; Canouil, M.* ; Chai, X.* ; Chen, Y.D.I.* ; Chen, X.* ; Chitrala, K.N.* ; Concas, M.P.* ; de Faire, U.* ; de Mutsert, R.* ; de Silva, H.J.* ; de Vries, P.S.* ; Do, A.N.* ; Faul, J.D.* ; Fisher, V.* ; Floyd, J.S.* ; Forrester, T.* ; Friedlander, Y.* ; Girotto, G.* ; Gu, C.C.* ; Hallmans, G.* ; Heikkinen, S.* ; Heng, C.K.* ; Homuth, G.* ; Hunt, S.* ; Ikram, M.A.* ; Jacobs, D.R.* ; Kavousi, M.* ; Khor, C.C.* ; Kilpeläinen, T.O.* ; Koh, W.P.* ; Komulainen, P.* ; Langefeld, C.D.* ; Liang, J.* ; Peters, A. ; Raitakari, O.T.* ; Waldenberger, M. ; Wilson, G.* ; Xuan, D.* ; Yao, J.* ; Gieger, C. ; Jonas, J.B.* ; Kato, N.* ; Lakka, T.* ; Meitinger, T. ; Milaneschi, Y.* ; Nauck, M.* ; Palmer, N.D.* ; Strauch, K. ; Sims, M.* ; Bonnefond, A.* ; Fox, E.R.* ; Fornage, M.*

Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.

Front. Genet. 14:1235337 (2023)
Publ. Version/Full Text DOI PMC
Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was performed while accounting for gene-educational attainment interactions in up to 226,315 individuals from five population groups. We considered two educational attainment variables: “Some College” (yes/no, for any education beyond high school) and “Graduated College” (yes/no, for completing a 4-year college degree). Genome-wide significant (p < 5 × 10−8) and suggestive (p < 1 × 10−6) variants were identified in Stage 1 (in up to 108,784 individuals) through genome-wide analysis, and those variants were followed up in Stage 2 studies (in up to 117,531 individuals). Results: In combined analysis of Stages 1 and 2, we identified 18 novel lipid loci (nine for LDL, seven for HDL, and two for TG) by two degree-of-freedom (2 DF) joint tests of main and interaction effects. Four loci showed significant interaction with educational attainment. Two loci were significant only in cross-population analyses. Several loci include genes with known or suggested roles in adipose (FOXP1, MBOAT4, SKP2, STIM1, STX4), brain (BRI3, FILIP1, FOXP1, LINC00290, LMTK2, MBOAT4, MYO6, SENP6, SRGAP3, STIM1, TMEM167A, TMEM30A), and liver (BRI3, FOXP1) biology, highlighting the potential importance of brain-adipose-liver communication in the regulation of lipid metabolism. An investigation of the potential druggability of genes in identified loci resulted in five gene targets shown to interact with drugs approved by the Food and Drug Administration, including genes with roles in adipose and brain tissue. Discussion: Genome-wide interaction analysis of educational attainment identified novel lipid loci not previously detected by analyses limited to main genetic effects.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Cholesterol ; Educational Attainment ; Genome-wide Association Study ; Lipids ; Meta-analysis ; Triglycerides; Coronary-heart-disease; Environment Interaction; Adipocyte Differentiation; Socioeconomic-status; Lipoprotein-lipase; Insulin-resistance; Transgenic Mice; Adipose-tissue; Blood-pressure; Risk-factors
ISSN (print) / ISBN 1664-8021
e-ISSN 1664-8021
Journal Frontiers in Genetics
Quellenangaben Volume: 14, Issue: , Pages: , Article Number: 1235337 Supplement: ,
Publisher Frontiers
Publishing Place Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)
Institute of Human Genetics (IHG)
Institute of Genetic Epidemiology (IGE)
Grants NHLBI
Intramural Research Program of the National Human Genome Research Institute, National Institutes of Health
U.S. National Heart, Lung, and Blood Institute (NHLBI), the National Institutes of Health