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as soon as is submitted to ZB.
Fatty tissue as a modulator of cancer cell mechanics.
Proc. SPIE 12649, DOI: 10.1117/12.2681388 (2023)
The viscoelastic properties of cells are an essential physical parameter in many biological processes. A crucial example is the softening of cancer cells during the metastatic cascade. The drivers behind the change in cell mechanics are still not fully understood and the mechanical properties of the substrate, the ECM, and crosstalk with other cells often influence measurements of cell mechanics.We used the optical stretcher (OS), a dual laser beam trap, to measure the active and passive viscoelastic properties of cancer cells in suspension. We compare cancerous cells with and without co-culturing them with adipose tissue cells. With this assay, we can investigate the impact of the cellular crosstalk between the cancerous and adipose tissue cells on the physical properties of cells, thereby disentangling it from any substrate effects. Our goal is to understand how cancer cells are able to migrate through soft fatty tissue and what mechanical properties are essential during this process.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cell Mechanics ; Optical Stretcher ; Physics Of Cancer
ISSN (print) / ISBN
0277-786X
e-ISSN
1996-756X
Journal
Proceedings of SPIE
Quellenangaben
Volume: 12649
Publisher
SPIE
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)