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Sadafi, A. ; Hehr, M. ; Navab, N.* ; Marr, C.

A Study of Age and Sex Bias in Multiple Instance Learning Based Classification of Acute Myeloid Leukemia Subtypes.

In: (Clinical Image-Based Procedures, Fairness of AI in Medical Imaging, and Ethical and Philosophical Issues in Medical Imaging). Berlin [u.a.]: Springer, 2023. 256-265 (Lect. Notes Comput. Sc. ; 14242 LNCS)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Accurate classification of Acute Myeloid Leukemia (AML) subtypes is crucial for clinical decision-making and patient care. In this study, we investigate the potential presence of age and sex bias in AML subtype classification using Multiple Instance Learning (MIL) architectures. To that end, we train multiple MIL models using different levels of sex imbalance in the training set and excluding certain age groups. To assess the sex bias, we evaluate the performance of the models on male and female test sets. For age bias, models are tested against underrepresented age groups in the training data. We find a significant effect of sex and age bias on the performance of the model for AML subtype classification. Specifically, we observe that females are more likely to be affected by sex imbalance dataset and certain age groups, such as patients with 72 to 86 years of age with the RUNX1::RUNX1T1 genetic subtype, are significantly affected by an age bias present in the training data. Ensuring inclusivity in the training data is thus essential for generating reliable and equitable outcomes in AML genetic subtype classification, ultimately benefiting diverse patient populations.
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Publication type Article: Conference contribution
Corresponding Author
Keywords Acute Myeloid Leukemia ; Age Bias ; Fairness ; Multiple Instance Learning ; Sex Bias
ISSN (print) / ISBN 0302-9743
e-ISSN 1611-3349
Conference Title Clinical Image-Based Procedures, Fairness of AI in Medical Imaging, and Ethical and Philosophical Issues in Medical Imaging
Journal Lecture Notes in Computer Science
Quellenangaben Volume: 14242 LNCS, Issue: , Pages: 256-265 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Berlin [u.a.]
Non-patent literature Publications
Institute(s) Institute of AI for Health (AIH)
Grants European Research Council (ERC) under the European Union