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Shahrokny, P.* ; Maison, N. ; Riemann, L.* ; Ehrmann, M.* ; Deluca, D.* ; Schuchardt, S.* ; Thiele, D.* ; Weckmann, M.* ; Dittrich, A.M.* ; Schaub, B.* ; Brinkmann, F.* ; Hansen, G.* ; Kopp, M.V.* ; von Mutius, E. ; Rabe, K.F.* ; Bahmer, T.* ; Hohlfeld, J.M.* ; Grychtol, R.* ; Holz, O.*

Increased breath naphthalene in children with asthma and wheeze of the All Age Asthma Cohort (ALLIANCE).

J. Breath Res. 18:016003 (2024)

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Exhaled breath contains numerous volatile organic compounds (VOCs) known to be related to lung disease like asthma. Its collection is non-invasive, simple to perform and therefore an attractive method for the use even in young children. We analysed breath in children of the multicenter All Age Asthma Cohort (ALLIANCE) to evaluate if ‘breathomics’ have the potential to phenotype patients with asthma and wheeze, and to identify extrinsic risk factors for underlying disease mechanisms. A breath sample was collected from 142 children (asthma: 51, pre-school wheezers: 55, healthy controls: 36) and analysed using gas chromatography-mass spectrometry (GC/MS). Children were diagnosed according to Global Initiative for Asthma guidelines and comprehensively examined each year over up to seven years. Forty children repeated the breath collection after 24 or 48 months. Most breath VOCs differing between groups reflect the exposome of the children. We observed lower levels of lifestyle-related VOCs and higher levels of the environmental pollutants, especially naphthalene, in children with asthma or wheeze. Naphthalene was also higher in symptomatic patients and in wheezers with recent inhaled corticosteroid use. No relationships with lung function or TH2 inflammation were detected. Increased levels of naphthalene in asthmatics and wheezers and the relationship to disease severity could indicate a role of environmental or indoor air pollution for the development or progress of asthma. Breath VOCs might help to elucidate the role of the exposome for the development of asthma. The study was registered at ClinicalTrials.gov (NCT02496468).

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Alliance ; Exhaled Air ; Pediatric Asthma ; Voc ; Wheeze; Volatile Organic-compounds; Personal Exposure; Childhood Asthma; Exhaled Breath; Indoor

ISSN (print) / ISBN 1752-7155

e-ISSN 1752-7163

Journal Journal of Breath Research

Quellenangaben Volume: 18, Issue: 1, Article Number: 016003

Publisher Institute of Physics Publishing (IOP)

Publishing Place Temple Circus, Temple Way, Bristol Bs1 6be, England

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Asthma and Allergy Prevention (IAP)

Grants We would like to express our gratitude to Manfred Elend (dagger 17.04.21). Without his extraordinary experience in GC-MS analysis and his valuable advice, we would not have been able to collect the data of this study.