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Sidulova, M.* ; Sun, X. ; Gossmann, A.*

Deep Unsupervised Clustering for Conditional Identification of Subgroups Within a Digital Pathology Image Set.

In: (Medical Image Computing and Computer Assisted Intervention – MICCAI 2023). Berlin [u.a.]: Springer, 2023. 666-675 (Lect. Notes Comput. Sc. ; 14227 LNCS)
DOI
Consideration of subgroups or domains within medical image datasets is crucial for the development and evaluation of robust and generalizable machine learning systems. To tackle the domain identification problem, we examine deep unsupervised generative clustering approaches for representation learning and clustering. The Variational Deep Embedding (VaDE) model is trained to learn lower-dimensional representations of images based on a Mixture-of-Gaussians latent space prior distribution while optimizing cluster assignments. We propose the Conditionally Decoded Variational Deep Embedding (CDVaDE) model which incorporates additional variables of choice, such as the class labels, as conditioning factors to guide the clustering towards subgroup structures in the data which have not been known or recognized previously. We analyze the behavior of CDVaDE on multiple datasets and compare it to other deep clustering algorithms. Our experimental results demonstrate that the considered models are capable of separating digital pathology images into meaningful subgroups. We provide a general-purpose implementation of all considered deep clustering methods as part of the open source Python package DomId (https://github.com/DIDSR/DomId ).
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Publication type Article: Conference contribution
Corresponding Author
Keywords Deep Clustering ; Domain Identification ; Generative Model ; Subgroup Identification ; Variational Autoencoder
ISSN (print) / ISBN 0302-9743
e-ISSN 1611-3349
Conference Title Medical Image Computing and Computer Assisted Intervention – MICCAI 2023
Journal Lecture Notes in Computer Science
Quellenangaben Volume: 14227 LNCS, Issue: , Pages: 666-675 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Berlin [u.a.]
Non-patent literature Publications
Institute(s) Institute of AI for Health (AIH)