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Jourdan, C. ; Kloiber, S.* ; Nieters, A.* ; Seiler, H.* ; Himmerich, H.* ; Kohli, M.A.* ; Lucae, S.* ; Wolfram, G.* ; Gieger, C. ; Wichmann, H.-E. ; Linseisen, J.

Gene-PUFA interactions and obesity risk.

Br. J. Nutr. 106, 1263-1272 (2011)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Although there are indications for modulatory effects of PUFA on associations between SNP and obesity risk, scientific evidence in human subjects is still scarce. The present analyses investigated interaction effects between SNP in candidate genes for obesity and PUFA in erythrocyte membranes on obesity risk. Within the second Bavarian Food Consumption Survey (cross-sectional, population-based), 568 adults provided blood samples. Fatty acid composition of erythrocyte membranes was analysed by means of GC. Genotyping was performed for twenty-one genes, including cytokines, adipokines, neurotransmitters and transcription factors. In addition, plasma IL-6 concentrations were analysed. For the statistical analysis, a logistic regression model assuming additive genetic effects was chosen. About 20 % of the study participants were classified as obese (BMI ≥ 30 kg/m(2)). Several significant gene-PUFA interactions were found, indicating regulatory effects of PUFA by gene variants of IL-2, IL-6, IL-18, TNF receptor family member 1B and 21, leptin receptor and adiponectin on obesity risk. After stratification by genotype, the strongest effects were found for rs2069779 (IL-2) and all tested PUFA as well as for rs1800795 (IL-6) and linoleic or arachidonic acid. The obesity risk of minor allele carriers significantly decreased with increasing fatty acid content. The genetic PUFA-IL-6 interaction was also reflected in plasma IL-6 concentrations. If replicated in a prospective study with sufficient statistical power, the results would indicate a beneficial effect of high PUFA supply for a substantial proportion of the population with respect to obesity risk.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Obesity; Gene-PUFA interactions; Nutritional biomarkers; Bavarian Food Consumption Survey II
ISSN (print) / ISBN 0007-1145
e-ISSN 1475-2662
Journal British Journal of Nutrition
Quellenangaben Volume: 106, Issue: 8, Pages: 1263-1272 Article Number: , Supplement: ,
Publisher Cambridge Univ. Press
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Genetic Epidemiology (IGE)
Research Unit Molecular Epidemiology (AME)