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Gutmann, D.* ; Dressler, M.* ; Eickmeier, O.* ; Herrmann, E.* ; Kirwil, M.* ; Schubert, R.* ; Zielen, S.* ; Zissler, U.M.

Proinflammatory pattern in the lower airways of non-asthmatic obese adolescents.

Cytokine 173:156452 (2023)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
BACKGROUND: Obesity is known to be a pro-inflammatory condition affecting multiple organs. Obesity as a systemic pro-inflammatory state, might be associated with bronchial inflammation in non-smoking adolescents with a BMI ≥ 30 kg/m2 without evidence of concomitant chronic diseases. MATERIALS AND METHODS: We studied non-asthmatic obese patients (n = 20; median age 15.8 years; BMI 35.0 kg/m2) compared to age matched healthy control subjects (n = 20; median age 17.5 years; BMI 21.5 kg/m2). Induced sputum differential cell counts and sputum mRNA levels were assessed for all study subjects. Serum levels of CRP, IL-6, and IL-8 were measured. Further, IL-5, IL-6, IL-8, IL-13, IL-17, TNF-α, IFN-γ, and IP-10 protein levels were analyzed in induced sputum was. RESULTS: Serum CRP levels, sputum inflammatory cell load and sputum eosinophils differed significantly between obese and non-obese subjects, for sputum neutrophils, a correlation was shown with BMI ≥ 30 kg/m2. Differences were also observed for sputum mRNA expression of IL6, IL8, IL13, IL17, IL23, and IFN-γ, as well as the transcription factors T-bet, GATA3, and FoxP3. CONCLUSIONS: Increased bronchial inflammation, triggered by systemic or local inflammatory effects of obesity itself, may account for the higher rates of airway disease in obese adolescents.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Adolescents ; Bronchial Inflammation ; Inflammation Pattern ; Lung ; Obesity; Body-mass Index; Inflammation; Asthma; Association; Innate; Sputum; Il-23; Il-12; Exacerbation; Cytokine
ISSN (print) / ISBN 1043-4666
e-ISSN 1096-0023
Journal Cytokine
Quellenangaben Volume: 173, Issue: , Pages: , Article Number: 156452 Supplement: ,
Publisher Elsevier
Publishing Place Oxford [u.a.]
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute for Allergy Research (IAF)
Grants Dr. Marschner Foundation
German Research Foundation (DFG)
German Center for Lung Research (DZL)