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Open Access Green as soon as Postprint is submitted to ZB.
Eryptosis: A driver of anemia in chronic kidney disease.
Curr. Opin. Nephrol. Hypertens. 33, 220-225 (2023)
PURPOSE OF REVIEW: Anemia, characterized by a reduction in red blood cell (RBC) count or hemoglobin concentration, commonly accompanies chronic kidney disease (CKD), significantly impacting patients' quality of life. This review delves into the multifaceted nature of anemia in CKD, with a focus on novel mechanisms, particularly the dysregulation of eryptosis or programmed cell death of RBCs, leading to shortened RBC lifespan. RECENT FINDINGS: Recent studies in CKD patients and mouse models revealed that eryptosis, driven by factors such as uremic toxins, inflammation, and imbalances in calcium homeostasis, plays a pivotal role in the development of renal anemia. Dysregulated eryptosis results in premature RBC destruction, exacerbating the hypoproliferative character of anemia in CKD. SUMMARY: Recognizing the intricate relationship between eryptosis and anemia in CKD opens promising prospects for improving patient outcomes and enhancing our understanding of this complex condition. Future research and therapeutic development in this area hold the potential to improve anemia treatment of CKD patients.
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Publication type
Article: Journal article
Document type
Review
Keywords
anemia; chronic kidney disease; eryptosis; lifespan; red blood cell death; Impact; Serum
ISSN (print) / ISBN
1062-4821
e-ISSN
1473-6554
Quellenangaben
Volume: 33,
Issue: 2,
Pages: 220-225
Publisher
Lippincott Williams & Wilkins
Publishing Place
Two Commerce Sq, 2001 Market St, Philadelphia, Pa 19103 Usa
Reviewing status
Peer reviewed
Grants
German Research Foundation