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Novel markers and networks related to restored skeletal muscle transcriptome after bariatric surgery.
Obesity 32, 363-375 (2024)
Objective: The aim of this study was to discover novel markers underlying the improvement of skeletal muscle metabolism after bariatric surgery. Methods: Skeletal muscle transcriptome data of lean people and people with obesity, before and 1 year after bariatric surgery, were subjected to weighted gene co-expression network analysis (WGCNA) and least absolute shrinkage and selection operator (LASSO) regression. Results of LASSO were confirmed in a replication cohort. Results: The expression levels of 440 genes differing between individuals with and without obesity were no longer different 1 year after surgery, indicating restoration. WGCNA clustered 116 genes with normalized expression in one major module, particularly correlating to weight loss and decreased plasma free fatty acids (FFA), 44 of which showed an obesity-related phenotype upon deletion in mice. Among the genes of the major module, 105 represented prominent markers for reduced FFA concentration, including 55 marker genes for decreased BMI in both the discovery and replication cohorts. Conclusions: Previously unknown gene networks and marker genes underlined the important role of FFA in restoring muscle gene expression after bariatric surgery and further suggest novel therapeutic targets for obesity.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Weight-loss; Insulin; Pathophysiology; Management; Mechanisms; Obesity; C1-10
ISSN (print) / ISBN
1930-7381
e-ISSN
1930-739X
Journal
Obesity
Quellenangaben
Volume: 32,
Issue: 2,
Pages: 363-375
Publisher
Wiley
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Experimental Genetics (IEG)
Grants
German Diabetes Society
German Federal Ministry of Health
Brandenburg State
Schmutzler Stiftung
Ministry of Culture and Science of the State of North Rhine-Westfalia
German Science Foundation
German Research Foundation
German Ministry of Education and Research
German Federal Ministry of Health
Brandenburg State
Schmutzler Stiftung
Ministry of Culture and Science of the State of North Rhine-Westfalia
German Science Foundation
German Research Foundation
German Ministry of Education and Research