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Niyazi, M.* ; Zehentmayr, F.* ; Niemöller, O.M.* ; Eigenbrod, S.* ; Kretzschmar, H.* ; Osthoff, K.S.* ; Tonn, J.C.* ; Atkinson, M.J. ; Mörtl, S. ; Belka, C.*

MiRNA expression patterns predict survival in glioblastoma.

Radiat. Oncol. 6:153 (2011)
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In order to define new prognostic subgroups in patients with glioblastoma a miRNA screen (> 1000 miRNAs) from paraffin tissues followed by a bio-mathematical analysis was performed. 35 glioblastoma patients treated between 7/2005 - 8/2008 at a single institution with surgery and postoperative radio(chemo)therapy were included in this retrospective analysis. For microarray analysis the febit biochip "Geniom® Biochip MPEA homo-sapiens" was used. Total RNA was isolated from FFPE tissue sections and 1100 different miRNAs were analyzed. It was possible to define a distinct miRNA expression pattern allowing for a separation of distinct prognostic subgroups. The defined miRNA pattern was significantly associated with early death versus long-term survival (split at 450 days) (p = 0.01). The pattern and the prognostic power were both independent of the MGMT status. At present, this is the first dataset defining a prognostic role of miRNA expression patterns in patients with glioblastoma. Having defined such a pattern, a prospective validation of this observation is required.
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Publication type Article: Journal article
Document type Scientific Article
Keywords radiotherapy; glioblastoma; microRNA; methylation; prognosis
Language english
Publication Year 2011
HGF-reported in Year 2011
ISSN (print) / ISBN 1748-717X
e-ISSN 1748-717X
Journal Radiation Oncology
Quellenangaben Volume: 6, Issue: 1, Pages: , Article Number: 153 Supplement: ,
Publisher BioMed Central
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Biology (ISB)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Radiation Sciences
PSP Element(s) G-500200-001
PubMed ID 22074483
DOI 10.1186/1748-717X-6-153
Scopus ID 80755189632
Erfassungsdatum 2011-12-31
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