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Environmental exposure and sensitization patterns in a Swiss alpine pediatric cohort.
World Allergy Organiz. J. 16:100847 (2023)
BACKGROUND: The level of environmental exposure throughout life may contribute to the prevalence of allergic sensitization and allergic disease. The alpine climate has been considered a healthy climate with little allergen exposure and pollution. We conducted a cross-sectional study to investigate local environmental exposure and concomitant prevalence of allergic sensitization among local school children born and raised in an alpine environment. METHODS: Clinical and demographic data were collected with a questionnaire. Allergen content was assessed in residential settled dust samples, lifetime exposure to pollen and air pollution was calculated using data from national pollen and air pollution monitoring stations, and the allergic sensitization profile was determined with component resolved diagnostics (ISAC®). Univariate and multivariate regression models were used to estimate the relation between exposure and sensitization. RESULTS: In a cohort of children born and raised in an alpine environment, sensitization to aeroallergens is quite common (38%), especially to grass (33%) and cat (16%). House dust mite allergen was detected in up to 38% of residential dust samples, but sensitization to HDM was low (2.5%). Pollutant levels were low, but an increasing trend was observed in the amount of ozone and PM10. Living close to a busy road was associated with increased odds OR (95% CI) for being sensitized to any allergen 2.7 (1.0-7.2), to outdoor allergens 2.8 (1.1-7.1) and being sensitized plus reporting symptoms of rhinoconjunctivitis 4.4 (1.3-14.8) and asthma 5.5 (1.4-21). Indoor living conditions, including the presence of visible mold, increased the odds of being sensitized to indoor allergens (1.9 (1.1-3.2) and being sensitized plus reporting symptoms of rhinoconjunctivitis 1.9 (1.0-3.6) and asthma 2.1 (1.0-4.1). CONCLUSION: In a healthy alpine environment, pollution might still be an important factor contributing to allergic sensitization.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Allergic Sensitization ; Alpine ; Environment ; Exposure ; Pollution; Air-pollution Exposure; European Birth Cohorts; Allergic Sensitization; Dampness Exposure; Childhood Asthma; Children; Association; Pollen; Metaanalysis; Prevalence
e-ISSN
1939-4551
Quellenangaben
Volume: 16,
Issue: 12,
Article Number: 100847
Publisher
BioMed Central
Publishing Place
Radarweg 29, 1043 Nx Amsterdam, Netherlands
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Environmental Medicine (IEM)
Institute for Allergy Research (IAF)
Institute for Allergy Research (IAF)
Grants
CK-CARE Individual project grant