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Open Access Green as soon as Postprint is submitted to ZB.
The homeobox gene CDX2 is aberrantly expressed and associated with an inferior prognosis in patients with acute lymphoblastic leukemia.
Leukemia 23, 649-655 (2009)
Molecular characterization of acute lymphoblastic leukemia (ALL) has greatly improved the ability to categorize and prognostify patients with this disease. In this study, we show that the proto-oncogene CDX2 is aberrantly expressed in the majority of cases with B-lineage ALL and T-ALL. High expression of CDX2 correlated significantly with the ALL subtype pro-B ALL, cALL, Ph+ ALL and early T-ALL. Furthermore, high expression of CDX2 was associated with inferior overall survival and showed up as a novel and strong risk factor for ALL in bivariate analysis. Functional analyses showed that overexpression of Cdx2 in murine bone marrow progenitors perturbed genes involved in lymphoid development and that depletion of CDX2 in the human ALL cell line Nalm6 inhibited colony formation. These data indicate that aberrant CDX2 expression occurs frequently and has prognostic impact in adult patients with ALL.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
CDX2; acute lymphoblastic leukemia; HOX genes; prognostic factor; acute myeloid-leukemia; t(12/13)(p13;q12); leukemogenesis; progenitors; adult; mouse; model
ISSN (print) / ISBN
0887-6924
e-ISSN
1476-5551
Journal
Leukemia
Quellenangaben
Volume: 23,
Issue: 4,
Pages: 649-655
Publisher
Nature Publishing Group
Reviewing status
Peer reviewed
Institute(s)
CCG Pathogenesis of Acute Myeloid Leukemia (KKG-KPL)