PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Karna, B. ; Pellegata, N.S. ; Mohr, H.

Animal and cell culture models of PPGLs - Achievements and limitations.

Horm. Metab. Res. 56, 51-64 (2024)
Postprint DOI PMC
Open Access Green
Research on rare tumors heavily relies on suitable models for basic and translational research. Paragangliomas (PPGL) are rare neuroendocrine tumors (NET), developing from adrenal (pheochromocytoma, PCC) or extra-adrenal (PGL) chromaffin cells, with an annual incidence of 2-8 cases per million. While most PPGL cases exhibit slow growth and are primarily treated with surgery, limited systemic treatment options are available for unresectable or metastatic tumors. Scarcity of appropriate models has hindered PPGL research, preventing the translation of omics knowledge into drug and therapy development. Human PPGL cell lines are not available, and few animal models accurately replicate the disease's genetic and phenotypic characteristics. This review provides an overview of laboratory models for PPGLs, spanning cellular, tissue, organ, and organism levels. We discuss their features, advantages, and potential contributions to diagnostics and therapeutics. Interestingly, it appears that in the PPGL field, disease models already successfully implemented in other cancers have not been fully explored.
Impact Factor
Scopus SNIP
Altmetric
2.000
0.000
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Review
Keywords pheochromocytoma; paraganglioma; PDX; SDHx; neuroendocrine tumor; Metastatic Pheochromocytoma; Molecular Characterization; Paraganglioma Xenografts; Transcriptome Analysis; Signaling Pathways; Adrenal-gland; Mouse Model; Growth-rate; In-vivo; Sdhb
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 0018-5043
e-ISSN 1439-4286
Journal Hormone and Metabolic Research
Quellenangaben Volume: 56, Issue: 1, Pages: 51-64 Article Number: , Supplement: ,
Publisher Thieme
Publishing Place Rudigerstr 14, D-70469 Stuttgart, Germany
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
POF-Topic(s) 30201 - Metabolic Health
90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502590-001
G-501900-251
Grants Deutsche Forschungsgemeinschaft (CRC/Transregio 205 The Adrenal: Central Relay in Health and Disease)
DOI 10.1055/a-2204-4549
WOS ID 001135677800011
Scopus ID 85181626907
PubMed ID 38171372
Erfassungsdatum 2024-01-07
[➜Report correction]