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Vogli, M. ; Peters, A. ; Wolf, K. ; Thorand, B. ; Herder, C.* ; Koenig, W.* ; Cyrys, J. ; Maestri, E.* ; Marmiroli, N.* ; Karrasch, S. ; Zhang, S. ; Pickford, R.

Long-term exposure to ambient air pollution and inflammatory response in the KORA study.

Sci. Total Environ. 912:169416 (2024)
DOI PMC
Creative Commons Lizenzvertrag
Open Access Green as soon as Postprint is submitted to ZB.
Previous studies consistently showed an association between fine atmospheric particulate matter (PM2.5) and cardiovascular diseases. Concerns about adverse health effects of ultrafine particles (UFP) are growing but long-term studies are still scarce. In this study, we examined the association between long-term exposure to ambient air pollutants and blood biomarkers of inflammation and coagulation, including fibrinogen, high-sensitivity C-reactive protein (hs-CRP), serum amyloid A (SAA) adiponectin and interleukin-6 (IL-6), measured in the German KORA-S4 cohort study (1999-2001). IL-6 was available for older participants only, who were therefore considered as a subsample. Annual mean concentrations of UFP (as particle number concentration), particulate matter in different particles sizes (PM10, PMcoarse, PM2.5, PM2.5 absorbance), ozone (O3), and nitrogen oxides (NO2, NOX) were estimated by land-use regression models and assigned to participants' home addresses. We performed a multiple linear regression between each pollutant and each biomarker with adjustment for confounders. Per 1 interquartile range (IQR, 1945 particles/cm3) increase of UFP, fibrinogen increased by 0.70 % (0.04; 1.37) and hs-CRP increased by 3.16 % (-0.52; 6.98). Adiponectin decreased by -2.53 % (-4.78; -0.24) per 1 IQR (1.4 μg/m3) increase of PM2.5. Besides, PM2.5 was associated with increased IL-6 in the subsample. In conclusion, we observed that long-term exposure to air pollutants, including both fine and ultrafine particles, was associated with higher concentrations of pro-inflammatory and lower concentrations of an anti-inflammatory blood biomarkers, which is consistent with an increased risk for cardiovascular disease observed for long-term exposure to air pollutants.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Fine Particles ; Inflammatory Blood Markers ; Particulate Matter ; Ultrafine Particles; Particulate Matter; Subclinical Inflammation; Socioeconomic-status; Markers; Biomarkers; Interleukin-6; Association; Coagulation; Disease; Protein
ISSN (print) / ISBN 0048-9697
e-ISSN 1879-1026
Journal Science of the Total Environment, The
Quellenangaben Volume: 912, Issue: , Pages: , Article Number: 169416 Supplement: ,
Publisher Elsevier
Publishing Place Radarweg 29, 1043 Nx Amsterdam, Netherlands
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)
Institute of Epidemiology (EPI)
Grants Bavarian State Ministry for Environment and Consumer Protection
State of Bavaria
German Federal Ministry of Education and Research (BMBF)
Helmholtz Zentrum Muenchen - German Research Center for Environmental Health