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Eyerich, S. ; Onken, A.T.* ; Weidinger, S.* ; Franke, A.* ; Nasorri, F.* ; Pennino, D.* ; Grosber, M.* ; Pfab, F.* ; Schmidt-Weber, C.B. ; Mempel, M.* ; Hein, R.* ; Ring, J.* ; Cavani, A.* ; Eyerich, K.*

Mutual antagonism of T cells causing psoriasis and atopic eczema.

N. Engl. J. Med. 365, 231-238 (2011)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The simultaneous occurrence of psoriasis driven by type 1 helper T (Th1) cells and type 17 helper T (Th17) cells and atopic eczema dominated by type 2 helper T (Th2) cells is rare. Here, we describe three patients with co-occurring psoriasis and atopic eczema with an antagonistic course and distinct T-cell infiltrates in lesions from psoriasis and those from atopic eczema. Sensitized patients with psoriasis had a reaction to epicutaneous allergen challenge, with clinically and histologically verified eczema lesions containing a large number of allergen-reactive T cells. These findings support a causative role for T cells triggered by specific antigens in both psoriasis and atopic eczema.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Path test; Disease; Dermatitis; Mechanisms; Expression; IL-17
ISSN (print) / ISBN 0028-4793
e-ISSN 1533-4406
Journal New England Journal of Medicine, The / NEJM
Quellenangaben Volume: 365, Issue: 3, Pages: 231-238 Article Number: , Supplement: ,
Publisher Massachusetts Medical Society (MMS)
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
Institute of Epidemiology (EPI)