Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
Publ. Version/Full Text
DOI
PMC
 |
|
|
as soon as is submitted to ZB.
Epstein-Barr virus-driven B cell lymphoma mediated by a direct LMP1-TRAF6 complex.
Nat. Commun. 15:414 (2024)
Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) drives viral B cell transformation and oncogenesis. LMP1’s transforming activity depends on its C-terminal activation region 2 (CTAR2), which induces NF-κB and JNK by engaging TNF receptor-associated factor 6 (TRAF6). The mechanism of TRAF6 recruitment to LMP1 and its role in LMP1 signalling remains elusive. Here we demonstrate that TRAF6 interacts directly with a viral TRAF6 binding motif within CTAR2. Functional and NMR studies supported by molecular modeling provide insight into the architecture of the LMP1-TRAF6 complex, which differs from that of CD40-TRAF6. The direct recruitment of TRAF6 to LMP1 is essential for NF-κB activation by CTAR2 and the survival of LMP1-driven lymphoma. Disruption of the LMP1-TRAF6 complex by inhibitory peptides interferes with the survival of EBV-transformed B cells. In this work, we identify LMP1-TRAF6 as a critical virus-host interface and validate this interaction as a potential therapeutic target in EBV-associated cancer.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Nf-kappa-b; Membrane-protein 1; Receptor-associated Factor-3; Terminal Kinase Pathway; Latent Membrane-protein-1; Binding-site; Traf-binding; Growth Transformation; Signal-transduction; Critical Regulator
ISSN (print) / ISBN
2041-1723
e-ISSN
2041-1723
Journal
Nature Communications
Quellenangaben
Volume: 15,
Issue: 1,
Article Number: 414
Publisher
Nature Publishing Group
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Signaling and Translation (SAT)
Institute of Structural Biology (STB)
Research Unit Gene Vector (AGV)
Institute of Structural Biology (STB)
Research Unit Gene Vector (AGV)
Grants
Deutsches Zentrum für Infektionsforschung (German Center for Infection Research)
Deutsche Forschungsgemeinschaft (German Research Foundation)
Deutsche Forschungsgemeinschaft (German Research Foundation)