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Niche-specific control of tissue function by regulatory T cells-Current challenges and perspectives for targeting metabolic disease.
Cell Metab. 36, 229-239 (2024)
Tissue regulatory T cells (Tregs) exert pivotal functions in both immune and metabolic regulation, maintaining local tissue homeostasis, integrity, and function. Accordingly, Tregs play a crucial role in controlling obesity-induced inflammation and supporting efficient muscle function and repair. Depending on the tissue context, Tregs are characterized by unique transcriptomes, growth, and survival factors and T cell receptor (TCR) repertoires. This functional specialization offers the potential to selectively target context-specific Treg populations, tailoring therapeutic strategies to specific niches, thereby minimizing potential side effects. Here, we discuss challenges and perspectives for niche-specific Treg targeting, which holds promise for highly efficient and precise medical interventions to combat metabolic disease.
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Publication type
Article: Journal article
Document type
Review
Keywords
Adcs ; Car Tregs ; T2d ; Treg Engineering ; Antibody-drug Conjugates ; Bispecific Antibodies ; Bsabs ; Immunometabolism ; Personalized Medicines ; Therapeutic Treg Targeting ; Tissue Treg ; Tissue Treg Targeting In Distinct Niches ; Type 2 Diabetes; Visceral Adipose-tissue; Skeletal-muscle; Reg Cells; Insulin-resistance; Ppar-gamma; Accumulation; Population; Colitis; Gene; Suppression
ISSN (print) / ISBN
1550-4131
e-ISSN
1932-7420
Journal
Cell Metabolism
Quellenangaben
Volume: 36,
Issue: 2,
Pages: 229-239
Publisher
Elsevier
Publishing Place
50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status
Peer reviewed
Institute(s)
Research Unit Type 1 Diabetes Immunology (TDI)
Grants
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
Ludwig-Maximilians-Universitat Munchen
German Center for Diabetes Research (DZD)
Helmholtz Munich Innovation and Translation Fund 2023
EFSD/JDRF/Lilly Program on Type 1 Diabetes Research 2020
Research Group at Helmholtz Zentrum Munchen of the Deutsche Forschungsgemeinschaft
Excellence Program for Outstanding Female Scientists from the Helmholtz Association
Ludwig-Maximilians-Universitat Munchen
German Center for Diabetes Research (DZD)
Helmholtz Munich Innovation and Translation Fund 2023
EFSD/JDRF/Lilly Program on Type 1 Diabetes Research 2020
Research Group at Helmholtz Zentrum Munchen of the Deutsche Forschungsgemeinschaft
Excellence Program for Outstanding Female Scientists from the Helmholtz Association