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New retinoblastoma (RB) drug delivery approaches: Anti-tumor effect of atrial natriuretic peptide (ANP)-conjugated hyaluronic-acid-coated gold nanoparticles for intraocular treatment of chemoresistant RB.
Mol. Oncol. 18, 832-849 (2024)
Intraocular drug delivery is a promising approach for treatment of ocular diseases. Chemotherapeutic drugs used in retinoblastoma (RB) treatment often lead to side effects and drug resistances. Therefore, new adjuvant therapies are needed to treat chemoresistant RBs. Biocompatible gold nanoparticles (GNPs) have unique antiangiogenic properties and can inhibit cancer progression. The combination of gold and low-molecular-weight hyaluronan (HA) enhances the stability of GNPs and promotes the distribution across ocular barriers. Attached to HA-GNPs, the atrial natriuretic peptide (ANP), which diminishes neovascularization in the eye, is a promising new therapeutic agent for RB treatment. In the study presented, we established ANP-coupled HA-GNPs and investigated their effect on the tumor formation potential of chemoresistant RB cells in an in ovo chicken chorioallantoic membrane model and an orthotopic in vivo RB rat eye model. Treatment of etoposide-resistant RB cells with ANP-HA-GNPs in ovo resulted in significantly reduced tumor growth and angiogenesis compared with controls. The antitumorigenic effect could be verified in the rat eye model, including a noninvasive application form via eye drops. Our data suggest that ANP-HA-GNPs represent a new minimally invasive, adjuvant treatment option for RB.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Anp ; Cam ; Chemoresistance ; Gold Nanoparticles ; Hyaluronic Acid ; Retinoblastoma; Pulmonary Resection; Cell-lines; Cancer; Growth; Angiogenesis; Chemotherapy; Inflammation; Phenotype; Model
ISSN (print) / ISBN
1574-7891
e-ISSN
1878-0261
Journal
Molecular Oncology
Quellenangaben
Volume: 18,
Issue: 4,
Pages: 832-849
Publisher
Elsevier
Publishing Place
Amsterdam [u.a.]
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes Research Type 1 (IDF)
Grants
Projekt DEAL
IMCES of the University of Duisburg-Essen
University of Duisburg-Essen
Else Kroner-Fresenius-Stiftung
IMCES of the University of Duisburg-Essen
University of Duisburg-Essen
Else Kroner-Fresenius-Stiftung