PuSH - Publication Server of Helmholtz Zentrum München: New retinoblastoma (RB) drug delivery approaches: Anti-tumor effect of atrial natriuretic peptide (ANP)-conjugated hyaluronic-acid-coated gold nanoparticles for intraocular treatment of chemoresistant RB.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Haase, A.* ; Miroschnikov, N.* ; Klein, S.* ; Doege, A.* ; Dünker, N.* ; Van Meenen, D.* ; Junker, A.* ; Göpferich, A.* ; Apaolaza Gallegos, S.P. ; Busch, M.A.*

New retinoblastoma (RB) drug delivery approaches: Anti-tumor effect of atrial natriuretic peptide (ANP)-conjugated hyaluronic-acid-coated gold nanoparticles for intraocular treatment of chemoresistant RB.

Mol. Oncol. 18, 832-849 (2024)

Publ. Version/Full Text

DOI

PMC

Abstract
Metrics
Extra information

Intraocular drug delivery is a promising approach for treatment of ocular diseases. Chemotherapeutic drugs used in retinoblastoma (RB) treatment often lead to side effects and drug resistances. Therefore, new adjuvant therapies are needed to treat chemoresistant RBs. Biocompatible gold nanoparticles (GNPs) have unique antiangiogenic properties and can inhibit cancer progression. The combination of gold and low-molecular-weight hyaluronan (HA) enhances the stability of GNPs and promotes the distribution across ocular barriers. Attached to HA-GNPs, the atrial natriuretic peptide (ANP), which diminishes neovascularization in the eye, is a promising new therapeutic agent for RB treatment. In the study presented, we established ANP-coupled HA-GNPs and investigated their effect on the tumor formation potential of chemoresistant RB cells in an in ovo chicken chorioallantoic membrane model and an orthotopic in vivo RB rat eye model. Treatment of etoposide-resistant RB cells with ANP-HA-GNPs in ovo resulted in significantly reduced tumor growth and angiogenesis compared with controls. The antitumorigenic effect could be verified in the rat eye model, including a noninvasive application form via eye drops. Our data suggest that ANP-HA-GNPs represent a new minimally invasive, adjuvant treatment option for RB.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Anp ; Cam ; Chemoresistance ; Gold Nanoparticles ; Hyaluronic Acid ; Retinoblastoma; Pulmonary Resection; Cell-lines; Cancer; Growth; Angiogenesis; Chemotherapy; Inflammation; Phenotype; Model

ISSN (print) / ISBN 1574-7891

e-ISSN 1878-0261

Journal Molecular Oncology

Quellenangaben Volume: 18, Issue: 4, Pages: 832-849

Publisher Elsevier

Publishing Place Amsterdam [u.a.]

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes Research Type 1 (IDF)

Grants Projekt DEAL
IMCES of the University of Duisburg-Essen
University of Duisburg-Essen
Else Kroner-Fresenius-Stiftung