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The multifaceted functions of TRPV4 and calcium oscillations in tissue repair.
Int. J. Mol. Sci. 25:18 (2024)
The transient receptor potential vanilloid 4 (TRPV4) specifically functions as a mechanosensitive ion channel and is responsible for conveying changes in physical stimuli such as mechanical stress, osmotic pressure, and temperature. TRPV4 enables the entry of cation ions, particularly calcium ions, into the cell. Activation of TRPV4 channels initiates calcium oscillations, which trigger intracellular signaling pathways involved in a plethora of cellular processes, including tissue repair. Widely expressed throughout the body, TRPV4 can be activated by a wide array of physicochemical stimuli, thus contributing to sensory and physiological functions in multiple organs. This review focuses on how TRPV4 senses environmental cues and thereby initiates and maintains calcium oscillations, critical for responses to organ injury, tissue repair, and fibrosis. We provide a summary of TRPV4-induced calcium oscillations in distinct organ systems, along with the upstream and downstream signaling pathways involved. In addition, we delineate current animal and disease models supporting TRPV4 research and shed light on potential therapeutic targets for modulating TRPV4-induced calcium oscillation to promote tissue repair while reducing tissue fibrosis.
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Publication type
Article: Journal article
Document type
Review
Keywords
Trpv4 ; Calcium Oscillations ; Fibrosis ; Tissue Repair; Potential Vanilloid 4; Nonselective Cation Channel; Gene-expression; Blood-pressure; Receptor; Activation; Differentiation; Stretch; Sensitivity; Dysfunction
ISSN (print) / ISBN
1422-0067
e-ISSN
1661-6596
Quellenangaben
Volume: 25,
Issue: 2,
Article Number: 18
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Regenerative Biology (IRBM)
Grants
European Research Council Consolidator