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Foscarini, A. ; Tricarico, R.* ; Gentile, F.* ; Satam, S. ; Mohr, H. ; Kiss-Toth, E.* ; Ranzani, G.N.* ; Pellegata, N.S.

Tribbles genes in gastric cancer: A tumor-suppressive role for TRIB2.

Genes 15:26 (2023)
Postprint DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Tribbles pseudokinases (TRIB1-3) are important signaling modulators involved in several cancers. However, their function in gastric cancer (GC) remains undefined. GC is still a deadly disease since the lack of sensitive and specific biomarkers for early diagnosis and therapy response prediction negatively affects patients' outcome. The identification of novel molecular players may lead to more effective diagnostic and therapeutic avenues. Therefore, we investigated the role of TRIB genes in gastric tumorigenesis. Data mining of the TCGA dataset revealed that chromosomal instability (CIN) tumors have lower TRIB2 and higher TRIB3 expression versus microsatellite instability (MSI)-high tumors, while TRIB1 levels are similar in both tumor types. Moreover, in CIN tumors, low TRIB2 expression is significantly associated with aggressive stage IV disease. As no studies on TRIB2 in GC are available, we focused on this gene for further in vitro analyses. We checked the effect of TRIB2 overexpression (OE) on MKN45 and NCI-N87 CIN GC cell lines. In MKN45 cells, TRIB2 OE reduced proliferation and colony formation ability and induced G2/M arrest, while it decreased the proliferation and cell motility of NCI-N87 cells. These effects were not mediated by the MAPK pathway. Our results suggest a tumor-suppressive function of TRIB2 in GC with a CIN phenotype.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Cin Phenotype ; Trib2 ; Tribbles ; Gastric Cancer ; Tumor Suppressor
ISSN (print) / ISBN 2073-4425
e-ISSN 2073-4425
Journal Genes
Quellenangaben Volume: 15, Issue: 1, Pages: , Article Number: 26 Supplement: ,
Publisher MDPI
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)