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Kirk, D.* ; Costeira, R.* ; Visconti, A.* ; Khan Mirzaei, M. ; Deng, L. ; Valdes, A.M.* ; Menni, C.*

Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health.

Cell Rep. 43:113728 (2024)
Publ. Version/Full Text DOI PMC
Creative Commons Lizenzvertrag
Cardiometabolic diseases are leading causes of mortality in Western countries. Well-established risk factors include host genetics, lifestyle, diet, and the gut microbiome. Moreover, gut bacterial communities and their activities can be altered by bacteriophages (also known simply as phages), bacteria-infecting viruses, making these biological entities key regulators of human cardiometabolic health. The manipulation of bacterial populations by phages enables the possibility of using phages in the treatment of cardiometabolic diseases through phage therapy and fecal viral transplants. First, however, a deeper understanding of the role of the phageome in cardiometabolic diseases is required. In this review, we first introduce the phageome as a component of the gut microbiome and discuss fecal viral transplants and phage therapy in relation to cardiometabolic diseases. We then summarize the current state of phageome research in cardiometabolic diseases and propose how the phageome might indirectly influence cardiometabolic health through gut bacteria and their metabolites.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Cp: Metabolism ; Cp: Microbiology ; Bacteriophage ; Cardiometabolic Diseases ; Fecal Virome Transplant ; Microbiome ; Obesity ; Phage Therapy ; Phageome; Virome; Host
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Journal Cell Reports
Quellenangaben Volume: 43, Issue: 2, Pages: , Article Number: 113728 Supplement: ,
Publisher Cell Press
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)
Grants
UKRI/MRC
Chronic Disease Research Foundation