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Agache, I.* ; Canelo-Aybar, C.* ; Annesi-Maesano, I.* ; Cecchi, L.* ; Rigau, D.* ; Rodríguez-Tanta, L.Y.* ; Nieto-Gutierrez, W.* ; Song, Y.* ; Cantero-Fortiz, Y.* ; Roqué, M.* ; Vasquez, J.C.* ; Sola, I.* ; Biagioni, B.* ; Chung, F.* ; D'Amato, G.* ; Damialis, A.* ; Del Giacco, S.* ; Vecillas, L.L.* ; Dominguez-Ortega, J.* ; Galán, C.* ; Gilles, S.* ; Giovannini, M.* ; Holgate, S.* ; Jeebhay, M.* ; Nadeau, K.* ; Quirce, S.* ; Sastre, J.* ; Traidl-Hoffmann, C. ; Walusiak-Skorupa, J.* ; Sousa-Pinto, B.* ; Alonso-Coello, P.* ; Salazar, J.* ; Jutel, M.* ; Akdis, C.*

The impact of outdoor pollution and extreme temperatures on asthma-related outcomes: A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma.

Allergy, DOI: 10.1111/all.16041 (2024)
DOI PMC
Free by publisher: Publ. Version/Full Text online available 04/2026
Air pollution is one of the biggest environmental threats for asthma. Its impact is augmented by climate change. To inform the recommendations of the EAACI Guidelines on the environmental science for allergic diseases and asthma, a systematic review (SR) evaluated the impact on asthma-related outcomes of short-term exposure to outdoor air pollutants (PM2.5, PM10, NO2 , SO2 , O3 , and CO), heavy traffic, outdoor pesticides, and extreme temperatures. Additionally, the SR evaluated the impact of the efficacy of interventions reducing outdoor pollutants. The risk of bias was assessed using ROBINS-E tools and the certainty of the evidence by using GRADE. Short-term exposure to PM2.5, PM10, and NO2 probably increases the risk of asthma-related hospital admissions (HA) and emergency department (ED) visits (moderate certainty evidence). Exposure to heavy traffic may increase HA and deteriorate asthma control (low certainty evidence). Interventions reducing outdoor pollutants may reduce asthma exacerbations (low to very low certainty evidence). Exposure to fumigants may increase the risk of new-onset asthma in agricultural workers, while exposure to 1,3-dichloropropene may increase the risk of asthma-related ED visits (low certainty evidence). Heatwaves and cold spells may increase the risk of asthma-related ED visits and HA and asthma mortality (low certainty evidence).
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Grade ; Asthma ; Extreme Temperatures ; Outdoor Pollution ; Systematic Review; Air-pollution; Pesticide Exposure; Childhood Asthma; Lung-function; Residential Proximity; Respiratory-diseases; Hospital Encounters; Ambient-temperature; Onset Asthma; Hong-kong
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Environmental Medicine (IEM)