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Agache, I.* ; Canelo-Aybar, C.* ; Annesi-Maesano, I.* ; Cecchi, L.* ; Biagioni, B.* ; Chung, F.* ; D'Amato, G.* ; Damialis, A.* ; Del Giacco, S.* ; De las Vecillas, L.* ; Dominguez-Ortega, J.* ; Galán, C.* ; Gilles, S.* ; Giovannini, M.* ; Holgate, S.* ; Jeebhay, M.* ; Nadeau, K.* ; Papadopoulos, N.G.* ; Quirce, S.* ; Sastre, J.* ; Traidl-Hoffmann, C. ; Walusiak-Skorupa, J.* ; Sousa-Pinto, B.* ; Salazar, J.* ; Rodríguez-Tanta, L.Y.* ; Cantero, Y.* ; Montesinos-Guevara, C.* ; Song, Y.* ; Alvarado-Gamarra, G.* ; Sola, I.* ; Alonso-Coello, P.* ; Nieto-Gutierrez, W.* ; Jutel, M.* ; Akdis, C.A.*

The impact of indoor pollution on asthma-related outcomes: A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma.

Allergy, DOI: 10.1111/all.16051 (2024)
DOI PMC
Free by publisher: Publ. Version/Full Text online available 04/2026
Systematic review using GRADE of the impact of exposure to volatile organic compounds (VOCs), cleaning agents, mould/damp, pesticides on the risk of (i) new-onset asthma (incidence) and (ii) adverse asthma-related outcomes (impact). MEDLINE, EMBASE and Web of Science were searched for indoor pollutant exposure studies reporting on new-onset asthma and critical and important asthma-related outcomes. Ninety four studies were included: 11 for VOCs (7 for incidenceand 4 for impact), 25 for cleaning agents (7 for incidenceand 8 for impact), 48 for damp/mould (26 for incidence and 22 for impact) and 10 for pesticides (8 for incidence and 2 for impact). Exposure to damp/mould increases the risk of new-onset wheeze (moderate certainty evidence). Exposure to cleaning agents may be associated with a higher risk of new-onset asthma and with asthma severity (low level of certainty). Exposure to pesticides and VOCs may increase the risk of new-onset asthma (very low certainty evidence). The impact on asthma-related outcomes of all major indoor pollutants is uncertain. As the level of certainty is low or very low for most of the available evidence on the impact of indoor pollutants on asthma-related outcomes more rigorous research in the field is warranted.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Grade ; Asthma ; Guideline ; Indoor Pollution ; Systematic Review; Volatile Organic-compounds; Adult-onset Asthma; Occupational Risk-factors; Respiratory Symptoms; Childhood Asthma; Moisture Damage; Cleaning Agents; 1st Year; Airway Responsiveness; Residential Exposure
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Environmental Medicine (IEM)