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as soon as is submitted to ZB.
Lipid sensing nuclear receptors involved in the pathogenesis of fatty liver disease.
FEBS Lett., DOI: 10.1002/1873-3468.14818 (2024)
Non-alcoholic fatty liver disease (NAFLD) begins with lipid accumulation and progresses toward inflammation and fibrosis. Nuclear receptors (NRs), like the Peroxisome Proliferator-Activated Receptors alpha and gamma (PPARα and PPARy), the Farnesoid X Receptor (FXR), and the Liver X receptor (LXR), regulate genes by heterodimerizing with Retinoid X receptor (RXR). These receptors are emerging targets for pharmaceutical intervention for metabolic diseases.
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Publication type
Article: Journal article
Document type
Letter to the Editor
Keywords
Fxr ; Lxr ; Nafld ; Nash ; Pparalpha ; Ppargamma ; Fibrosis ; Nuclear Receptors; Farnesoid X Receptor; Nonalcoholic Steatohepatitis; Ppar-alpha; Bile-acid; Cholesterol; Metabolism; Fibrosis; Agonist
ISSN (print) / ISBN
0014-5793
e-ISSN
1873-3468
Journal
FEBS Letters
Publisher
Elsevier
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Endocrinology (IDE)
Institute of Diabetes and Cancer (IDC)
Institute of Diabetes and Cancer (IDC)
Grants
German Research Foundation DFG