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Mercado, L.* ; Rose, S.* ; Escalona-Vargas, D.* ; Siegel, E.R.* ; Whittington, J.R.* ; Preissl, H. ; Helmich, M.* ; Eswaran, H.*

Correlation of fetal heart rate dynamics to inflammatory markers and brain-derived neurotrophic factor during pregnancy.

J. Perinat. Med., DOI: 10.1515/jpm-2023-0413 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
OBJECTIVES: This study aims to show the relation between biomarkers in maternal and cord-blood samples and fetal heart rate variability (fHRV) metrics through a non-invasive fetal magnetocardiography (fMCG) technique. METHODS: Twenty-three women were enrolled for collection of maternal serum and fMCG tracings immediately prior to their scheduled cesarean delivery. The umbilical cord blood was collected for measurement of biomarker levels. The fMCG metrics were then correlated to the biomarker levels from the maternal serum and cord blood. RESULTS: Brain-derived neurotrophic factor (BDNF) had a moderate correlation with fetal parasympathetic activity (0.416) and fetal sympathovagal ratios (-0.309; -0.356). Interleukin (IL)-6 also had moderate-sized correlations but with an inverse relationship as compared to BDNF. These correlations were primarily in cord-blood samples and not in the maternal blood. CONCLUSIONS: In this small sample-sized exploratory study, we observed a moderate correlation between fHRV and cord-blood BDNF and IL-6 immediately preceding scheduled cesarean delivery at term. These findings need to be validated in a larger population.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Brain-derived Neurotrophic Factor (bdnf) ; Fetal Heart Rate Variability ; Fetal Magnetocardiography ; Inflammatory Markers (il-6); Rate-variability; Factor Bdnf; Cord; Neuroinflammation; Connectivity; Activation; Depression; Birth
ISSN (print) / ISBN 0300-5577
e-ISSN 1619-3997
Journal Journal of Perinatal Medicine
Publisher de Gruyter
Publishing Place Genthiner Strasse 13, D-10785 Berlin, Germany
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
Grants National Institute of Biomedical Imaging and Bioengineering