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Demko, V.* ; Belova, T.* ; Messerer, M. ; Hvidsten, T.R.* ; Perroud, P.F.* ; Ako, A.E.* ; Johansen, W.* ; Mayer, K.F.X. ; Olsen, O.A.* ; Lang, D.

Regulation of developmental gatekeeping and cell fate transition by the calpain protease DEK1 in Physcomitrium patens.

Comm. Biol. 7:261 (2024)

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Calpains are cysteine proteases that control cell fate transitions whose loss of function causes severe, pleiotropic phenotypes in eukaryotes. Although mainly considered as modulatory proteases, human calpain targets are directed to the N-end rule degradation pathway. Several such targets are transcription factors, hinting at a gene-regulatory role. Here, we analyze the gene-regulatory networks of the moss Physcomitrium patens and characterize the regulons that are misregulated in mutants of the calpain DEFECTIVE KERNEL1 (DEK1). Predicted cleavage patterns of the regulatory hierarchies in five DEK1-controlled subnetworks are consistent with a pleiotropic and regulatory role during cell fate transitions targeting multiple functions. Network structure suggests DEK1-gated sequential transitions between cell fates in 2D-to-3D development. Our method combines comprehensive phenotyping, transcriptomics and data science to dissect phenotypic traits, and our model explains the protease function as a switch gatekeeping cell fate transitions potentially also beyond plant development.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Defective Kernel 1; 3d Growth Transition; Transcription Factors; Arabidopsis; Model; Maize; Phosphoproteomics; Specification; Initiation; Prediction

ISSN (print) / ISBN 2399-3642

e-ISSN 2399-3642

Journal Communications Biology

Quellenangaben Volume: 7, Issue: 1, Article Number: 261

Publisher Springer

Publishing Place London

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Research Unit Plant Genome and Systems Biology (PGSB)

Grants Slovak Research and Development Agency
FRIMEDBIO grant from the Norwegian Research Council
Southeastern Regional Health Authorities
Functional Genomics and Infrastructure programs of the Research Council of Norway
Norwegian Research Council
FRIMEDBIO
Norges Forskningsrd (Research Council of Norway)