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Seiringer, P.* ; Hillig, C. ; Schäbitz, A.* ; Jargosch, M. ; Pilz, A.C.* ; Eyerich, S. ; Szegedi, A.* ; Sochorová, M.* ; Gruber, F.* ; Zouboulis, C.C.* ; Biedermann, T.* ; Menden, M.P. ; Eyerich, K.* ; Törőcsik, D.*

Spatial transcriptomics reveals altered lipid metabolism and inflammation-related gene expression of sebaceous glands in psoriasis and atopic dermatitis.

Front. Immunol. 15:1334844 (2024)
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Sebaceous glands drive acne, however, their role in other inflammatory skin diseases remains unclear. To shed light on their potential contribution to disease development, we investigated the spatial transcriptome of sebaceous glands in psoriasis and atopic dermatitis patients across lesional and non-lesional human skin samples. Both atopic dermatitis and psoriasis sebaceous glands expressed genes encoding key proteins for lipid metabolism and transport such as ALOX15B, APOC1, FABP7, FADS1/2, FASN, PPARG, and RARRES1. Also, inflammation-related SAA1 was identified as a common spatially variable gene. In atopic dermatitis, genes mainly related to lipid metabolism (e.g. ACAD8, FADS6, or EBP) as well as disease-specific genes, i.e., Th2 inflammation-related lipid-regulating HSD3B1 were differentially expressed. On the contrary, in psoriasis, more inflammation-related spatially variable genes (e.g. SERPINF1, FKBP5, IFIT1/3, DDX58) were identified. Other psoriasis-specific enriched pathways included lipid metabolism (e.g. ACOT4, S1PR3), keratinization (e.g. LCE5A, KRT5/7/16), neutrophil degranulation, and antimicrobial peptides (e.g. LTF, DEFB4A, S100A7-9). In conclusion, our results show that sebaceous glands contribute to skin homeostasis with a cell type-specific lipid metabolism, which is influenced by the inflammatory microenvironment. These findings further support that sebaceous glands are not bystanders in inflammatory skin diseases, but can actively and differentially modulate inflammation in a disease-specific manner.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Atopic Dermatitis (ad) ; Inflammatory Skin Diseases ; Lipid Metabolism ; Psoriasis ; Sebaceous Glands ; Spatial Transcriptomics; Proliferator-activated Receptor; Growth-factor-i; Antimicrobial Peptides; Linoleic-acid; Human Skin; Sebum; Pathway; Identification; Individuals; Desaturase
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 1664-3224
e-ISSN 1664-3224
Journal Frontiers in Immunology
Quellenangaben Volume: 15, Issue: , Pages: , Article Number: 1334844 Supplement: ,
Publisher Frontiers
Publishing Place Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)
Institute for Allergy Research (IAF)
POF-Topic(s) 30205 - Bioengineering and Digital Health
30202 - Environmental Health
Research field(s) Enabling and Novel Technologies
Allergy
PSP Element(s) G-554700-001
G-505490-001
Grants Hungarian National Research, Development and Innovation Office
Hans und Klementia Langmatz Stiftung
Federal Ministry for Digital and Economic Affairs of Austria
National Foundation for Research, Technology, and Development of Austria to the Christian Doppler Laboratory for Skin Multimodal Imaging of Aging
Deutsche Forschungsgemeinschaft (DFG) through TUM International Graduate School of Science and Engineering (IGSSE)
DOI 10.3389/fimmu.2024.1334844
WOS ID 001174117000001
Scopus ID 85186470038
PubMed ID 38433843
Erfassungsdatum 2024-04-26
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