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Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: A nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC).
EBioMedicine 101:105024 (2024)
BACKGROUND: Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain. METHODS: In a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined associations between pre-diagnostic circulating concentrations of 97 lipid metabolites (acylcarnitines, glycerophospholipids and sphingolipids) and colorectal cancer risk. Circulating lipids were measured using targeted mass spectrometry in 1591 incident colorectal cancer cases (55% women) and 1591 matched controls. Multivariable conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between concentrations of individual lipid metabolites and metabolite patterns with colorectal cancer risk. FINDINGS: Of the 97 assayed lipids, 24 were inversely associated (nominally p < 0.05) with colorectal cancer risk. Hydroxysphingomyelin (SM (OH)) C22:2 (ORper doubling 0.60, 95% CI 0.47-0.77) and acylakyl-phosphatidylcholine (PC ae) C34:3 (ORper doubling 0.71, 95% CI 0.59-0.87) remained associated after multiple comparisons correction. These associations were unaltered after excluding the first 5 years of follow-up after blood collection and were consistent according to sex, age at diagnosis, BMI, and colorectal subsite. Two lipid patterns, one including 26 phosphatidylcholines and all sphingolipids, and another 30 phosphatidylcholines, were weakly inversely associated with colorectal cancer. INTERPRETATION: Elevated pre-diagnostic circulating levels of SM (OH) C22:2 and PC ae C34:3 and lipid patterns including phosphatidylcholines and sphingolipids were associated with lower colorectal cancer risk. This study may provide insight into potential links between specific lipids and colorectal cancer development. Additional prospective studies are needed to validate the observed associations. FUNDING: World Cancer Research Fund (reference: 2013/1002); European Commission (FP7: BBMRI-LPC; reference: 313010).
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Acylcarnitines ; Colorectal Cancer ; Glycerophospholipids ; Lipids ; Metabolomics ; Sphingolipids; C-reactive Protein; Treelet Transform; Fatty-acids; Serum; Colon; Metaanalysis; Patterns; Database; Choline; Markers
Language
english
Publication Year
2024
HGF-reported in Year
2024
ISSN (print) / ISBN
2352-3964
e-ISSN
2352-3964
Journal
EBioMedicine
Quellenangaben
Volume: 101,
Article Number: 105024
Publisher
Elsevier
Publishing Place
Amsterdam [u.a.]
Reviewing status
Peer reviewed
POF-Topic(s)
30505 - New Technologies for Biomedical Discoveries
30201 - Metabolic Health
30201 - Metabolic Health
Research field(s)
Enabling and Novel Technologies
Genetics and Epidemiology
Genetics and Epidemiology
PSP Element(s)
A-630710-001
G-500600-001
G-500600-001
Grants
European Commission
World Cancer Research Fund
World Cancer Research Fund
WOS ID
001196987900001
Scopus ID
85187658965
PubMed ID
38412638
Erfassungsdatum
2024-04-30