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Ratter-Rieck, J.M.* ; Shi, M. ; Suhre, K.* ; Prehn, C. ; Adamski, J. ; Rathmann, W.* ; Thorand, B. ; Roden, M.* ; Peters, A. ; Wang-Sattler, R. ; Herder, C.*

Omentin associates with serum metabolite profiles indicating lower diabetes risk: KORA F4 Study.

BMJ Open Diab. Res. Care 12:e003865 (2024)
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INTRODUCTION: Circulating omentin levels have been positively associated with insulin sensitivity. Although a role for adiponectin in this relationship has been suggested, underlying mechanisms remain elusive. In order to reveal the relationship between omentin and systemic metabolism, this study aimed to investigate associations of serum concentrations of omentin and metabolites. RESEARCH DESIGN AND METHODS: This study is based on 1124 participants aged 61-82 years from the population-based KORA (Cooperative Health Research in the Region of Augsburg) F4 Study, for whom both serum omentin levels and metabolite concentration profiles were available. Associations were assessed with five multivariable regression models, which were stepwise adjusted for multiple potential confounders, including age, sex, body mass index, waist-to-hip ratio, lifestyle markers (physical activity, smoking behavior and alcohol consumption), serum adiponectin levels, high-density lipoprotein cholesterol, use of lipid-lowering or anti-inflammatory medication, history of myocardial infarction and stroke, homeostasis model assessment 2 of insulin resistance, diabetes status, and use of oral glucose-lowering medication and insulin. RESULTS: Omentin levels significantly associated with multiple metabolites including amino acids, acylcarnitines, and lipids (eg, sphingomyelins and phosphatidylcholines (PCs)). Positive associations for several PCs, such as diacyl (PC aa C32:1) and alkyl-alkyl (PC ae C32:2), were significant in models 1-4, whereas those with hydroxytetradecenoylcarnitine (C14:1-OH) were significant in all five models. Omentin concentrations were negatively associated with several metabolite ratios, such as the valine-to-PC ae C32:2 and the serine-to-PC ae C32:2 ratios in most models. CONCLUSIONS: Our results suggest that omentin may influence insulin sensitivity and diabetes risk by changing systemic lipid metabolism, but further mechanistic studies investigating effects of omentin on metabolism of insulin-sensitive tissues are needed.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Adipokines ; Biomarkers ; Lipids ; Type 2 Diabetes; Type-2; Adiponectin; Population; Acylcarnitines; Metabolomics; Progression; Mellitus
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 2052-4897
e-ISSN 2052-4897
Journal BMJ Open Diabetes Research & Care
Quellenangaben Volume: 12, Issue: 2, Pages: , Article Number: e003865 Supplement: ,
Publisher BMJ Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Translational Genomics (ITG)
CF Metabolomics & Proteomics (CF-MPC)
Institute of Experimental Genetics (IEG)
Institute of Epidemiology (EPI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
30505 - New Technologies for Biomedical Discoveries
30201 - Metabolic Health
30202 - Environmental Health
Research field(s) Genetics and Epidemiology
Enabling and Novel Technologies
PSP Element(s) G-506700-001
A-630710-001
G-500600-001
G-504000-002
G-504000-010
G-504090-001
Grants Munich Center of Health Sciences (MC- Health), Ludwig- Maximilians- Universitaet, Munich, Germany
State of Bavaria
German Federal Ministry of Education and Research
Helmholtz Zentrum Muenchen-German Research Center for Environmental Health
German Federal Ministry of Education and Research (BMBF) through the German Center for Diabetes Research (DZD)
Ministry of Culture and Science of the state North Rhine- Westphalia (Duesseldorf, Germany)
German Federal Ministry of Health (Berlin, Germany)
DOI 10.1136/bmjdrc-2023-003865
WOS ID 001239471900001
Scopus ID 85187140766
PubMed ID 38442989
Erfassungsdatum 2024-04-11
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